oncogene-induced senescence

Known as: OIS, oncogene-induced cell senescence 
A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2018
020406019812018

Papers overview

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Highly Cited
2009
Highly Cited
2009
Cellular senescence suppresses cancer by stably arresting the proliferation of damaged cells. Paradoxically, senescent cells also… (More)
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Highly Cited
2008
Highly Cited
2008
Oncogene-induced cellular senescence (OIS) is emerging as a potent cancer-protective response to oncogenic events, serving to… (More)
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Highly Cited
2008
Highly Cited
2008
Cells enter senescence, a state of stable proliferative arrest, in response to a variety of cellular stresses, including telomere… (More)
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Highly Cited
2007
Highly Cited
2007
Here we report that RNA interference against ATM inhibited p53 accumulation in cells expressing oncogenic STAT5 and cooperated… (More)
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Highly Cited
2007
Highly Cited
2007
Activating Ras mutations can induce either proliferation or senescence depending on the cellular context. To determine whether… (More)
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Highly Cited
2006
Highly Cited
2006
Recent studies have indicated the existence of tumorigenesis barriers that slow or inhibit the progression of preneoplastic… (More)
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Highly Cited
2006
Highly Cited
2006
Early tumorigenesis is associated with the engagement of the DNA-damage checkpoint response (DDR). Cell proliferation and… (More)
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Highly Cited
2006
Highly Cited
2006
Oncogene-induced senescence functions to limit tumor development. However, a complete understanding of the signals that trigger… (More)
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Highly Cited
2006
Highly Cited
2006
Recently, it has been shown that oncogene-induced senescence (OIS) occurs during the early stages of tumorigenesis. Senescent… (More)
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Highly Cited
2005
Highly Cited
2005
Most normal mammalian cells have a finite lifespan, thought to constitute a protective mechanism against unlimited proliferation… (More)
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