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ob/ob Mouse

Known as: ob/ob 
The obese mutant mouse was derived from a spontaneous mutation in a V/Le progenitor mouse at the Jackson Laboratory in 1949.
National Institutes of Health

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Papers overview

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1985
1985
Immunoreactive neurotensin in spontaneous syndromes of obesity and diabetes in mice.
Immunoreactive neurotensin was measured in plasma and acid-ethanol extracts of brain, intestine and pancreas of obese… 
1982
1982
Alterations of brown adipose tissue in genetically obese (ob/ob) mice. I. Demonstration of loss of metabolic response to nerve stimulation and catecholamines and its partial recovery after fasting or…
Metabolic responses to electrical nerve stimulation or norepinephrine of isolated interscapular brown adipose tissue (BAT) from… 
Highly Cited
1981
Highly Cited
1981
Hepatic sodium-potassium-dependent ATPase in obesity.
IN a study by De Luise, Blackburn, and Flier,1 ouabain binding by sodium pumping units (sodium-potassium-ATPase) in red cells… 
1981
1981
Development of lipogenesis and insulin sensitivity in tissues of the ob/ob mouse.
Lipogenesis and insulin sensitivity are evaluated in adipose tissue, liver, and diaphragm of ob/ob and non-ob/ob mice. In ob/ob… 
1981
1981
Effects of Thyroid Hormone and Adrenalectomy on [Na+ + K+]ATPase in the ob/ob Mouse
The absence of the thyroid stimulation of hepatic [Na+ + K+]ATPase in obese (ob/ob) mice has been investigated. A wide range of… 
1980
1980
Age-dependent development of insulin resistance of soleus muscle in genetically obese (ob/ob) mice.
The relationship between insulin binding and its biological effects was studied in soleus muscle of 3- to 15-wk-old genetically… 
1979
1979
Maintenance energy requirements, energy retention and heat production of young obese (ob/ob) and lean mice fed a high-fat or a high-carbohydrate diet.
Female obese (ob/ob) and lean mice were weaned at 21 days of age, placed in wire-mesh cages maintained at 25 to 30 degrees, and… 
1979
1979
Effects of the obese (ob/ob) genotype on spleen cell immune function.
Spleen cells from mice homozygous for the obese (ob) mutation killed DBA/2 mastocytoma target cells less well than spleen cells… 
1979
1979
Gastrointestinal peptides in the brain.
Both immunoreactive intact cholecystokinin (CCK33) and its COOH-terminal octapeptide (CCK8) are detected in brain and gut… 
Highly Cited
1977
Highly Cited
1977
Effects of Adrenalectomy on Body Weight and Hyperglycemia in Five Months Old Ob/Ob Mice
Observation on body weight gain, blood glucose levels, and responses to a glucose challenge in ob/ob mice adrenalectomized at…