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ob/ob Mouse

Known as: ob/ob 
The obese mutant mouse was derived from a spontaneous mutation in a V/Le progenitor mouse at the Jackson Laboratory in 1949.
National Institutes of Health

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Clinical Data Interchange Standards Consortium Terminology

Papers overview

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Highly Cited
2005
Highly Cited
2005
Hypothalamic Control of Bone Formation: Distinct Actions of Leptin and Y2 Receptor Pathways
Leptin and Y2 receptors on hypothalamic NPY neurons mediate leptin effects on energy homeostasis; however, their interaction in… 
Highly Cited
2005
Highly Cited
2005
Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta.
Activators of peroxisome proliferator-activated receptor (PPAR)gamma have been studied intensively for their insulin-sensitizing… 
Highly Cited
2004
Highly Cited
2004
Hypothalamic cocaine- and amphetamine-regulated transcript neurons project to areas expressing gonadotropin releasing hormone immunoreactivity and to the anteroventral periventricular nucleus in male…
Highly Cited
2003
Highly Cited
2003
Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice
Obesity plays a central role in the development of insulin resistance and type 2 diabetes. We therefore examined the effects of a… 
Highly Cited
2001
Highly Cited
2001
Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation.
Fatty livers are sensitive to lipopolysaccharide (LPS) damage. This study tests the hypothesis that this vulnerability occurs… 
Highly Cited
1999
Highly Cited
1999
Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/obmice.
Because muscle triacylglycerol (TAG) accumulation might contribute to insulin resistance in leptin-deficient ob/obmice, we… 
Highly Cited
1996
Highly Cited
1996
Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice.
The obese gene product, leptin, is synthesized in adipose tissue and is a circulating factor regulating body weight. To identify… 
Highly Cited
1976
Highly Cited
1976
The development of obesity, hyperinsulinemia, and hyperglycemia in ob/ob mice.
Highly Cited
1975
Highly Cited
1975
The pituitary-adrenal system of the genetically obese (ob/ob) mouse.
Adult genetically obese (ob/ob) mice which are characterized by adrenal hypertrophy and increased secretion of corticosteroids… 
Highly Cited
1973
Highly Cited
1973
The effect of adrenalectomy on the development of the obese-hyperglycemic syndrome in ob-ob mice.
Adrenalectomy in the male and female obese-hyperglycemic mouse at 2 months of age significantly lowers blood glucose and body… 
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