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nifene

Known as: 2-fluoro-3-(2-(3-pyrrolinyl)methoxy)pyridine 
National Institutes of Health

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PyridinesPyrroles

Papers overview

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2016
2016
New Precursor in Improved 18F-Nifene Synthesis for Imaging Nicotinic Receptors
1086 Objectives The α4β2 nicotine acetylcholine receptor (nAChR) has been implicated in various neurodegenerative diseases. 18F… 
Review
2014
Review
2014
Neural nAChRs PET imaging probes
There have been a number of attempts to study PET radioligands for imaging nicotinic acetylcholine receptors (nAChRs) in the… 
2014
2014
Synthesis and evaluation of 2-(18)F-fluoro-5-iodo-3-[2-(S)-3,4-dehydropyrrolinylmethoxy]pyridine ((18)F-Niofene) as a potential imaging agent for nicotinic α4β2 receptors.
Nicotinic α4β2 acetylcholine receptors (nAChRs) have been implicated in various pathophysiologies including neurodegenerative… 
2013
2013
(-)-[(18) F]Flubatine: evaluation in rhesus monkeys and a report of the first fully automated radiosynthesis validated for clinical use.
(-)-[(18) F]Flubatine was selected for clinical imaging of α4 β2 nicotinic acetylcholine receptors because of its high affinity… 
2013
2013
Evaluation of experimental protocols to accurately measure {alpha}4{beta}2* nicotinic acetylcholine receptor density with 18F-nifene
2012
2012
PET Imaging of α4β2* Nicotinic Acetylcholine Receptors: Quantitative Analysis of 18F-Nifene Kinetics in the Nonhuman Primate
The PET radioligand 2-fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine (18F-nifene) is an α4β2* nicotinic acetylcholine receptor… 
2012
2012
Synthesis and evaluation of 3-¹²³I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic α4β2 receptor imaging agent.
2006
2006
Effect of acetylcholinesterase inhibitors on {alpha}4{beta}2 nAChR ligand, 18F-nifene: A measure of acetylcholine competition
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