neoantigens

As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune… (More)

Detection of lymphocytes that target tumor-specific mutant neoantigens—derived from products encoded by mutated genes in the… (More)

Cancer immunotherapy has gained significant momentum from recent clinical successes of checkpoint blockade inhibition. Massively… (More)

Accumulating evidence suggests that clinically efficacious cancer immunotherapies are driven by T cell reactivity against DNA… (More)

In successful cancer immunotherapy, T cell responses appear to be directed toward neoantigens created by somatic mutations… (More)

T cell immunity directed against tumor-encoded amino acid substitutions occurs in some melanoma patients. This implicates… (More)

Genome sequencing has revealed a large number of shared and personal somatic mutations across human cancers. In principle, any… (More)

Radiation can be used to guide drugs to specific sites such as neoplasms or aberrant blood vessels. When blood vessels are… (More)

OBJECTIVES To ascertain if immunization results in the restoration of responses to recall antigens, in the development of… (More)

Previous investigations have shown that antibodies in sera from patients with halothane hepatitis recognize neoantigens… (More)