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necrox-7

National Institutes of Health

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Organic Chemicals

Papers overview

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2018
2018
Abstract 465: Regulation of HMGB1 release protects chemoradiotherapy-associated mucositis
Oral mucositis (OM) is a common complication in cancer patients undergoing anticancer treatment. Despite the clinical and… 
2016
2016
NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice.
2016
2016
A New Chemical Compound, NecroX-7, Acts as a Necrosis Modulator by Inhibiting High-Mobility Group Box 1 Protein Release During Massive Ischemia-Reperfusion Injury.
2015
2015
The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T Cells and Inhibition of HMGB1 Release
Graft-versus-host disease (GVHD) is a major complication associated with allogeneic hematopoietic stem cell transplantation… 
2015
2015
The indole derivative NecroX‐7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation
Nonalcoholic steatohepatitis (NASH) is associated with cirrhosis and hepatocellular carcinoma. Reactive oxygen species (ROS) and… 
2014
2014
Abstract 2720:In vitroevaluation of a novel chemotherapeutic agent, NecroX-7, in human Burkitt lymphoma cells
NecroX-7 is a novel small molecule of the NecroX series, its chemical compound is C25H32N4O4S2 with molecular weight 516.67 based… 
2013
2013
An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice.
AIMS Acetaminophen (APAP)-induced liver injury is mainly due to the excessive formation of reactive oxygen species (ROS) and… 
2012
2012
NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats.
2010
2010
Effect of necrosis modulator necrox-7 on hepatic ischemia-reperfusion injury in beagle dogs.
2010
2010
Necrox-7 ® as an therapeutic candidate for the prevention of hepatic ischemic reperfusion injury
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