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natakalim

National Institutes of Health

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Allyl CompoundsPropylamines

Papers overview

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2016
2016
Analysis on mechanism of ATP-sensitive K+ channel opener natakalim improving congestive heart failure after myocardial infarction
The action mechanism of natakalim, a novel ATP-sensitive potassium channel opener, was studied in ameliorating the congestive… 
2016
2016
Pharmacological evidence: a new therapeutic approach to the treatment of chronic heart failure through SUR2B/Kir6.1 channel in endothelial cells
Both iptakalim (Ipt) and natakalim (Nat) activate the SUR2B/Kir6.1 channel, an ATP-sensitive potassium channel (KATP) subtype… 
2012
2012
[Protective effects of SUR2B/Kir6.1 potassium channel opener natakalim against RAVECs injuries induced by hypoxia].
OBJECTIVE To investigate the protective effects of natakalim against rat aortic vascular endothelial cells (RAVECs) injuries… 
2012
2012
[Activation of SUR2B/Kir6.1-type K(ATP) channels protects glomerular endothelial, mesangial and tubular epithelial cells against oleic acid renal damage].
Cumulative evidence suggests that renal vascular endothelial injury play an important role in initiating and extending tubular… 
2011
2011
Effects of natakalim on mitochondrial ATP-sensitive potassium channel in rat brain
Objective To investigate the effects of natakalim on mitochondrial ATP-sensitive potassium channel(mitoK_(ATP)) in rat brain… 
2010
2010
Activation of SUR2B/Kir6.1 Subtype of Adenosine Triphosphate-sensitive Potassium Channel Improves Pressure Overload-induced Cardiac Remodeling via Protecting Endothelial Function
We sought to explore new strategies targeting SUR2B/Kir6.1, a subtype of adenosine triphosphate (ATP)-sensitive potassium… 
2009
2009
The cardiovascular actions of natakalim,a highly selective opener of SUR2B/Kir6.1 subtype of ATP-sensitive potassuim channels
Aim To investigate the cardiovascular pharmacological effects of natakalim,a selective KATP channel SUR2B/Kir6.1 subtype opener… 
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