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nafimidone

Known as: 1-(2-naphthoylmethyl)imidazole 
National Institutes of Health

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2 relations

Broader (1)

Naphazoline
analogs & derivatives

Papers overview

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2017
2017
New Anti‐Seizure (Arylalkyl)azole Derivatives: Synthesis, In Vivo and In Silico Studies
(Arylalkyl)azoles are a class of antiepileptic compounds including nafimidone, denzimol, and loreclezole (LRZ). Nafimidone and… 
2012
2012
Synthesis and Anticonvulsant Activity of O-alkylated Derivatives of 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone Oxime
Abstract In this study, O-alkylated derivatives of nafimidone oxime chemically, 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime… 
2007
2007
Comparative 1-Substituted Imidazole Inhibition of Cytochrome P450 Isozyme-Selective Activities in Human and Mouse Hepatic Microsomes
Inhibition of cytochrome P450(CYP)-selective reactions in a single human and a single mouse hepatic microsome preparation by… 
Highly Cited
2001
Highly Cited
2001
Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities.
1991
1991
Pharmacokinetic consequences of product stereoselectivity in the metabolism of nafimidone: estimation of fraction metabolized.
The fraction of a dose of parent drug that is biotransformed to a specific metabolite is classically determined following… 
1988
1988
Interaction of the Anticonvulsants, Denzimol and Nafimidone, with Liver Cytochrome P450 in the Rat
Abstract— The presence of an imidazole moiety in the chemical structure of denzimol and nafimidone suggested that these new… 
1988
1988
The Significance of the Imidazole Ring in Anticonvulsant Activity of (Arylalkyl)imidazoles
The imidazole ring in nafimidone [1‐(2‐naphthyl)‐2‐(1‐imidazolyl)ethanone] was substituted with various groups to investigate the… 
1986
1986
Development of a stability-indicating assay for nafimidone [1-(2-naphthoylmethyl)imidazole hydrochloride] by high-performance liquid chromatography.
1985
1985
Efficacy of Nafimidone in the Treatment of Intractable Partial Seizures: Report of a Two‐Center Pilot Study
La nafimidone est une nouvelle drogue anti‐épileptique potentielle dont le profil thérapeutique sur les modèles animaux est… 
1983
1983
Simultaneous determination of nafimidone [1-(2-naphthoylmethyl)imidazole], a new anticonvulsant agent, and a major metabolite in plasma by high-performance liquid chromatography.
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