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mycolactone B

 
National Institutes of Health

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Macrolides

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2017
2017
ONIOM Method Characterization of Hydrogen Bonding Sites of Mycolactone A/B, a Buruli Ulcer Toxin
Mycolactone molecules are responsible of Buruli ulcer disease. In this work, we are interested in the geometric, energetic and… Expand
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2017
2017
Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer
Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans… Expand
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2017
2017
Modular total syntheses of mycolactone A/B and its [2H]-isotopologue.
A modular total synthesis of mycolactone A/B, the exotoxin produced by Mycobacterium ulcerans, has been achieved through the… Expand
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2016
2016
Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons
Background Mycolactone is a polyketide toxin secreted by the mycobacterium Mycobacterium ulcerans, responsible for the extensive… Expand
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2014
2014
Accelerated Detection of Mycolactone Production and Response to Antibiotic Treatment in a Mouse Model of Mycobacterium ulcerans Disease
Diagnosis of the neglected tropical disease, Buruli ulcer, can be made by acid-fast smear microscopy, specimen culture on… Expand
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2011
2011
Chemistry of mycolactones, the causative toxins of Buruli ulcer.
  • Yoshito Kishi
  • Proceedings of the National Academy of Sciences…
  • 2011
Buruli ulcer is a severe and devastating skin disease caused by Mycobacterium ulcerans infection, yet it is one of the most… Expand
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2010
2010
Detection of Mycolactone A/B in Mycobacterium ulcerans–Infected Human Tissue
BACKGROUND Mycobacterium ulcerans disease (Buruli ulcer) is a neglected tropical disease common amongst children in rural West… Expand
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2010
2010
A Mycobacterium ulcerans toxin, mycolactone, induces apoptosis in primary human keratinocytes and in HaCaT cells.
The pathogenicity of Mycobacterium ulcerans (Buruli ulcer) depends on cytotoxic effect of its exotoxin mycolactone. Since… Expand
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2005
2005
A newly discovered mycobacterial pathogen isolated from laboratory colonies of Xenopus species with lethal infections produces a novel form of mycolactone, the Mycobacterium ulcerans macrolide toxin.
Mycobacterium ulcerans, the causative agent of Buruli ulcer, produces a macrolide toxin, mycolactone A/B, which is thought to… Expand
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2003
2003
Uptake and cellular actions of mycolactone, a virulence determinant for Mycobacterium ulcerans.
Mycolactone is a macrolide secreted by Mycobacterium ulcerans. Experimental evidence suggests that mycolactone plays a prominent… Expand
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