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mitotic sister chromatid separation

Known as: mitotic sister chromatid resolution, sister chromatid separation during mitosis 
The process in which sister chromatids are physically detached from each other during mitosis. [GOC:ai]
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

mitotic sister chromatid segregation
positive regulation of mitotic sister chromatid separation

Papers overview

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Highly Cited
2015
Highly Cited
2015
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms
Mullenders et al. report that loss of cohesin alters stem cell homeostasis and myelopoiesis, facilitating the development of a… Expand
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Review
2012
Review
2012
Replication fork dynamics and the DNA damage response.
Prevention and repair of DNA damage is essential for maintenance of genomic stability and cell survival. DNA replication during S… Expand
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Highly Cited
2009
Highly Cited
2009
The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities
Loss-of-function of caretaker genes characterizes a group of cancer predisposition diseases that feature cellular… Expand
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Highly Cited
2005
Highly Cited
2005
Securin is overexpressed in breast cancer
Securin regulates sister chromatid separation during mitosis, induces bFGF-mediated angiogenesis, and securin overexpression… Expand
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Highly Cited
2003
Highly Cited
2003
Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes
The mammalian securin, pituitary tumor transforming gene (PTTG), regulates sister chromatid separation during mitosis. Mice or… Expand
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Highly Cited
2002
Highly Cited
2002
Regulation of Human Separase by Securin Binding and Autocleavage
BACKGROUND Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister… Expand
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2002
2002
Expression of hpttg proto-oncogene in lymphoid neoplasias
Pituitary tumor-transforming gene (pttg) is a distinct proto-oncogene which is expressed in certain normal tissues with high… Expand
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Highly Cited
2001
Highly Cited
2001
Drosophila separase is required for sister chromatid separation and binds to PIM and THR.
Drosophila PIM and THR are required for sister chromatid separation in mitosis and associate in vivo. Neither of these two… Expand
Highly Cited
1996
Highly Cited
1996
Separation of Sister Chromatids in Mitosis Requires the Drosophila pimples Product, a Protein Degraded after the Metaphase/Anaphase Transition
Mutations in the Drosophila genes pimples and three rows result in a defect of sister chromatid separation during mitosis. As a… Expand
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Highly Cited
1988
Highly Cited
1988
Cold‐sensitive and caffeine‐supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis.
We isolated novel classes of Schizosaccharomyces pombe cold‐sensitive dis mutants that block mitotic chromosome separation (nine… Expand
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