mitotic sister chromatid separation
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Mullenders et al. report that loss of cohesin alters stem cell homeostasis and myelopoiesis, facilitating the development of a… Expand Prevention and repair of DNA damage is essential for maintenance of genomic stability and cell survival. DNA replication during S… Expand Loss-of-function of caretaker genes characterizes a group of cancer predisposition diseases that feature cellular… Expand Securin regulates sister chromatid separation during mitosis, induces bFGF-mediated angiogenesis, and securin overexpression… Expand The mammalian securin, pituitary tumor transforming gene (PTTG), regulates sister chromatid separation during mitosis. Mice or… Expand BACKGROUND
Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister… Expand Pituitary tumor-transforming gene (pttg) is a distinct proto-oncogene which is expressed in certain normal tissues with high… Expand Drosophila PIM and THR are required for sister chromatid separation in mitosis and associate in vivo. Neither of these two… Expand Mutations in the Drosophila genes pimples and three rows result in a defect of sister chromatid separation during mitosis. As a… Expand We isolated novel classes of Schizosaccharomyces pombe cold‐sensitive dis mutants that block mitotic chromosome separation (nine… Expand