mitochondrial K(ATP) channel

Known as: mitoK(ATP), mitoKATP, mitochondrial K-ATP channel 
 
National Institutes of Health

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Potassium Channel

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Highly Cited
2012
Highly Cited
2012
Mitochondrial ROMK channel is a molecular component of mitoK(ATP).
RATIONALE Activation of the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) has been implicated in the mechanism of… (More)
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Highly Cited
2004
Highly Cited
2004
Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection.
Bradykinin (BK) mimics ischemic preconditioning by generating reactive oxygen species (ROS). To identify intermediate steps that… (More)
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Highly Cited
2002
Highly Cited
2002
Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways.
BACKGROUND Volatile anesthetics induce pharmacological preconditioning in cardiac tissue. The purpose of this study was to test… (More)
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Highly Cited
2002
Highly Cited
2002
Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice.
Recently it has been postulated that mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channels rather than sarcolemmal K(ATP) (sarcK… (More)
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2001
2001
Mitochondrial K(ATP) channel activation reduces anoxic injury by restoring mitochondrial membrane potential.
Mitochondrial membrane potential (DeltaPsi(m)) is severely compromised in the myocardium after ischemia-reperfusion and triggers… (More)
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2000
2000
Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning.
BACKGROUND Sublethal periods of ischemia preceding a prolonged interval of ischaemia protect the myocardium. This myocardial… (More)
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Highly Cited
1999
Highly Cited
1999
Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardium.
Growing evidence exists that ATP-sensitive mitochondrial potassium channels (MitoKATP channel) are a major contributor to the… (More)
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Highly Cited
1999
Highly Cited
1999
Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide.
Opening of mitochondrial ATP-sensitive (mitoKATP) channel with diazoxide induces an early phase (EP) of cardioprotection. It is… (More)
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Highly Cited
1998
Highly Cited
1998
Modulation of mitochondrial ATP-dependent K+ channels by protein kinase C.
Pharmacological openers of mitochondrial ATP-dependent K+ (mitoKATP) channels mimic ischemic preconditioning, and such… (More)
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Highly Cited
1998
Highly Cited
1998
State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate.
The mitochondrial KATP channel (mitoKATP) is hypothesized to be the receptor for the cardioprotective effects of K+ channel… (More)
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