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midbrain-hindbrain boundary development

Known as: MHB development, isthmic organizer development, isthmus development 
The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The… Expand
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

brain developmentrostrocaudal neural tube patterning

Narrower (2)

midbrain-hindbrain boundary initiationmidbrain-hindbrain boundary morphogenesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
CRISPR/Cas9-Mediated Zebrafish Knock-in as a Novel Strategy to Study Midbrain-Hindbrain Boundary Development
The midbrain-hindbrain boundary (MHB) acts as an organizer and controls the fate of neighboring cells to develop into either… Expand
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2013
2013
Corpus Callosum Area in Children and Adults with Autism.
Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum… Expand
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Highly Cited
2011
Highly Cited
2011
Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.
LIM homeodomain transcription factors, Lmx1a and Lmx1b, are required for the development of midbrain dopaminergic (mDA) neurons… Expand
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2010
2010
En2, Pax2/5 and Tcf-4 transcription factors cooperate in patterning the Xenopus brain.
Among Xenopus Lef/Tcfs, XTcf-4 has an outstanding role. In early development it is located exclusively in the midbrain where it… Expand
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2003
2003
Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons.
As many studies have focused on the mechanisms of motoneuron specification, little is known about the factors that control the… Expand
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Highly Cited
2002
Highly Cited
2002
A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines.
The pax2.1 gene encodes a paired-box transcription factor that is one of the earliest genes to be specifically activated in… Expand
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Highly Cited
2001
Highly Cited
2001
Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.
The anterior neural ridge (ANR), and the isthmic organiser (IsO) represent two signalling centres possessing organising… Expand
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Highly Cited
1998
Highly Cited
1998
A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary.
Generation of cell diversity in the vertebrate central nervous system starts during gastrulation stages in the ectodermal germ… Expand
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Highly Cited
1998
Highly Cited
1998
Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function.
The mammalian Pax2, Pax5 and Pax8 genes code for highly related transcription factors, which play important roles in embryonic… Expand
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Highly Cited
1989
Highly Cited
1989
Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse
The process of segmentation, in which repeated homologous structures are generated along the anterior–posterior axis of the… Expand
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