FAQ

midbrain-hindbrain boundary development

Known as: MHB development, isthmic organizer development, isthmus development 
The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The… (More)

Topic mentions per year

Topic mentions per year

1998-2017
012319982017

Related topics

Related topics

3 relations

Broader (1)

brain development

Narrower (2)

midbrain-hindbrain boundary initiationmidbrain-hindbrain boundary morphogenesis

Related mentions per year

Related mentions per year

1953-2018
1960198020002020
midbrain-hindbrain boundary development
brain development
midbrain-hindbrain boundary initiation
midbrain-hindbrain boundary morphogenesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
CRISPR/Cas9-Mediated Zebrafish Knock-in as a Novel Strategy to Study Midbrain-Hindbrain Boundary Development
The midbrain-hindbrain boundary (MHB) acts as an organizer and controls the fate of neighboring cells to develop into either… (More)
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2013
2013
Corpus Callosum Area in Children and Adults with Autism.
Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum… (More)
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2010
2010
En2, Pax2/5 and Tcf-4 transcription factors cooperate in patterning the Xenopus brain.
Among Xenopus Lef/Tcfs, XTcf-4 has an outstanding role. In early development it is located exclusively in the midbrain where it… (More)
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2009
2009
Zebrafish gbx1 refines the Midbrain-Hindbrain Boundary border and mediates the Wnt8 posteriorization signal
Studies in mouse, Xenopus and chicken have shown that Otx2 and Gbx2 expression domains are fundamental for positioning the… (More)
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2004
2004
Combinatorial Wnt control of zebrafish midbrain–hindbrain boundary formation
Wnt signaling is known to be required for the normal development of the vertebrate midbrain and hindbrain, but genetic loss of… (More)
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2002
2002
A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines.
The pax2.1 gene encodes a paired-box transcription factor that is one of the earliest genes to be specifically activated in… (More)
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Highly Cited
2000
Highly Cited
2000
Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development.
Pax2 and Pax5 arose by gene duplication at the onset of vertebrate evolution and have since diverged in their developmental… (More)
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Highly Cited
1998
Highly Cited
1998
Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis.
We describe the isolation of zebrafish Fgf8 and its expression during gastrulation, somitogenesis, fin bud and early brain… (More)
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Highly Cited
1998
Highly Cited
1998
A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary.
Generation of cell diversity in the vertebrate central nervous system starts during gastrulation stages in the ectodermal germ… (More)
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Highly Cited
1998
Highly Cited
1998
Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function.
The mammalian Pax2, Pax5 and Pax8 genes code for highly related transcription factors, which play important roles in embryonic… (More)
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