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methylosome

Known as: 20S methylosome, 20S methyltransferase complex, 20S methyltransferase complex location 
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The m6A Writer: Rise of a Machine for Growing Tasks.
The central dogma of molecular biology introduced by Crick describes a linear flow of information from DNA to mRNA to protein… 
Highly Cited
2016
Highly Cited
2016
m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination
N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain… 
2016
2016
MEP50/PRMT5 reduces gene expression by histone arginine methylation and this is reversed by PKCδ/p38δ signaling
PKCδ and p38δ are key proteins in a cascade that stimulates keratinocyte differentiation. This cascade activates transcription of… 
Highly Cited
2014
Highly Cited
2014
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
2013
2013
Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells.
Highly Cited
2012
Highly Cited
2012
Crystal structure of the human PRMT5:MEP50 complex
Protein arginine methyltransferases (PRMTs) play important roles in several cellular processes, including signaling, gene… 
2012
2012
Pinellia pedatisecta agglutinin interacts with the methylosome and induces cancer cell death
Pinellia pedatisecta agglutinin (PPA) is a specific mannose-binding plant lectin accumulated in the tuber of P. pedatisecta. In… 
Highly Cited
2002
Highly Cited
2002
A Novel WD Repeat Protein Component of the Methylosome Binds Sm Proteins*
We have recently described a large (20 S) protein arginine methyltransferase complex, termed the methylosome, that contains the… 
Review
2002
Review
2002
The SMN complex, an assemblyosome of ribonucleoproteins.
Highly Cited
2001
Highly Cited
2001
The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins
ABSTRACT snRNPs, integral components of the pre-mRNA splicing machinery, consist of seven Sm proteins which assemble in the… 
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