method development

 
National Institutes of Health

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MethodsR43 grantanalytical method

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Review
2017
Review
2017
Modeling and interpreting mesoscale network dynamics
Recent advances in brain imaging techniques, measurement approaches, and storage capacities have provided an unprecedented supply… (More)
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Highly Cited
2012
Highly Cited
2012
Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomics.
Selected reaction monitoring on a triple quadrupole mass spectrometer is currently experiencing a renaissance within the… (More)
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Highly Cited
2010
Highly Cited
2010
Protein-protein docking benchmark version 4.0.
We updated our protein-protein docking benchmark to include complexes that became available since our previous release. As before… (More)
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Review
2010
Review
2010
Systematic LC-MS/MS bioanalytical method development that incorporates plasma phospholipids risk avoidance, usage of incurred sample and well thought-out chromatography.
This treatise summarizes the underlying principle and the road map for systematic LC-MS/MS bioanalytical method development. The… (More)
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2010
2010
Protocol for solid-phase microextraction method development
Solid-phase microextraction (SPME) is a sample preparation method developed to solve some of the analytical challenges of sample… (More)
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Highly Cited
2009
Highly Cited
2009
Expediting the development of targeted SRM assays: using data from shotgun proteomics to automate method development.
Selected reaction monitoring (SRM) is a powerful tandem mass spectrometry method that can be used to monitor target peptides… (More)
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Highly Cited
2006
Highly Cited
2006
Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma.
Glycerophosphocholines (GPCho's) are known to cause liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) matrix… (More)
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Highly Cited
2005
Highly Cited
2005
Fit-for-Purpose Method Development and Validation for Successful Biomarker Measurement
Despite major advances in modern drug discovery and development, the number of new drug approvals has not kept pace with the… (More)
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Highly Cited
2003
Highly Cited
2003
Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation, and biofluid.
The purpose of the present work was to evaluate the synergistic effect of ionization type, sample preparation technique, and bio… (More)
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Highly Cited
1974
Highly Cited
1974
Criteria for judging precision and accuracy in method development and evaluation.
We describe an approach for formulating criteria that can be used to judge whether an analytical method has acceptable precision… (More)
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