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metacavir

National Institutes of Health

Papers overview

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2015
2015
Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats
Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent. The main targets of the toxic… 
2013
2013
Crystal structure of metacavir ethanol solvent compound
The ethanol solvent compounds was obtained via Metacavir recrystallization in ethanol,the structure was characterized by singl… 
2012
2012
Single crystal form of metacavir ethanol solvent compound and preparation method thereof
The invention relates to a single crystal form of a metacavir ethanol solvent compound and a preparation method thereof, as well… 
2011
2011
Evaluation of Mitochondrial Toxicity in Marmota himalayana Treated with Metacavir, a Novel 2′,3′-Dideoxyguanosine Prodrug for Treatment of Hepatitis B Virus
ABSTRACT Metacavir (PNA) is a novel synthetic nucleoside analogue for the treatment of hepatitis B virus (HBV). Our recent… 
2011
2011
Simultaneous determination of metacavir and its metabolites in rat plasma using high-performance liquid chromatography with tandem mass spectrometric detection (LC-MS/MS).
A sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of… 
2011
2011
Six-month repeated dose toxicity of orally administered metacavir in rhesus monkeys.
2010
2010
In Vitro Mitochondrial Toxicity of Metacavir, a New Nucleoside Reverse Transcriptase Inhibitor for Treatment of Hepatitis B Virus
ABSTRACT Therapy with nucleoside reverse transcriptase inhibitors (NRTIs) can be associated with mitochondrial toxicity. In vitro… 
2009
2009
In vivo assessment of mitochondrial toxicity of metacavir in Rhesus monkeys after three months of intravenous administration
AbstractAim:To explore the potential mitochondrial toxicities and their severities of intravenously administered metacavir, a… 
2008
2008
A sensitive and specific liquid chromatography-mass spectrometry method for determination of metacavir in rat plasma.
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