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memoquin

National Institutes of Health

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2 relations

Broader (2)

AlkanesEthylamines

Papers overview

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Highly Cited
2013
Highly Cited
2013
Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease
Alzheimer's disease (AD) is characterized by progressive loss of cognitive function, dementia and altered behavior. Over 30… Expand
Review
2011
Review
2011
Memoquin: A multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer’s disease
SummaryAlzheimer’s disease is currently thought to be a complex, multifactorial syndrome, unlikely to arise from a single causal… Expand
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2011
2011
Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.
Eight monomeric congeners, related to the multitarget lead candidate memoquin, were prepared and evaluated at multiple targets to… Expand
Highly Cited
2011
Highly Cited
2011
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.
Lipoic acid (LA) is a natural antioxidant. Its structure was previously combined with that of the acetylcholinesterase inhibitor… Expand
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Highly Cited
2011
Highly Cited
2011
Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.
Memoquin (1) is a lead compound multitargeted against Alzheimer's disease (AD). It is an AChE inhibitor, free-radical scavenger… Expand
Review
2009
Review
2009
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.
The multifunctional nature of Alzheimer's disease (AD) provides the logical foundation for the development of an innovative drug… Expand
Highly Cited
2009
Highly Cited
2009
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.
Novel multitargeted antioxidants 3-6 were designed by combining the antioxidant features, namely, a benzoquinone fragment and a… Expand
2009
2009
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.
The present article expands on the study of structure-activity relationships of the novel class of quinone-bearing polyamines, as… Expand
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Highly Cited
2007
Highly Cited
2007
Insight Into the Kinetic of Amyloid β (1–42) Peptide Self‐Aggregation: Elucidation of Inhibitors’ Mechanism of Action
The initial transition of amyloid β (1–42) (Aβ42) soluble monomers/small oligomers from unordered/α‐helix to a β‐sheet‐rich… Expand
Highly Cited
2007
Highly Cited
2007
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.
One of the characteristics of Alzheimer's disease (AD) that hinders the discovery of effective disease-modifying therapies is the… Expand
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