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memoquin

National Institutes of Health

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2 relations

Broader (2)

AlkanesEthylamines

Papers overview

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Highly Cited
2013
Highly Cited
2013
Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease
Alzheimer's disease (AD) is characterized by progressive loss of cognitive function, dementia and altered behavior. Over 30… 
2013
2013
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease.
Highly Cited
2011
Highly Cited
2011
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.
Highly Cited
2011
Highly Cited
2011
Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.
2011
2011
Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.
Eight monomeric congeners, related to the multitarget lead candidate memoquin, were prepared and evaluated at multiple targets to… 
Review
2011
Review
2011
Memoquin: A multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer’s disease
Review
2009
Review
2009
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.
The multifunctional nature of Alzheimer's disease (AD) provides the logical foundation for the development of an innovative drug… 
Highly Cited
2009
Highly Cited
2009
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.
Novel multitargeted antioxidants 3-6 were designed by combining the antioxidant features, namely, a benzoquinone fragment and a… 
Highly Cited
2007
Highly Cited
2007
Insight Into the Kinetic of Amyloid β (1–42) Peptide Self‐Aggregation: Elucidation of Inhibitors’ Mechanism of Action
The initial transition of amyloid β (1–42) (Aβ42) soluble monomers/small oligomers from unordered/α‐helix to a β‐sheet‐rich… 
Highly Cited
2007
Highly Cited
2007
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.
One of the characteristics of Alzheimer's disease (AD) that hinders the discovery of effective disease-modifying therapies is the… 
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