memoquin

Alzheimer's disease (AD) is characterized by progressive loss of cognitive function, dementia and altered behavior. Over 30… Expand

SummaryAlzheimer’s disease is currently thought to be a complex, multifactorial syndrome, unlikely to arise from a single causal… Expand

Eight monomeric congeners, related to the multitarget lead candidate memoquin, were prepared and evaluated at multiple targets to… Expand

Lipoic acid (LA) is a natural antioxidant. Its structure was previously combined with that of the acetylcholinesterase inhibitor… Expand

Memoquin (1) is a lead compound multitargeted against Alzheimer's disease (AD). It is an AChE inhibitor, free-radical scavenger… Expand

The multifunctional nature of Alzheimer's disease (AD) provides the logical foundation for the development of an innovative drug… Expand

Novel multitargeted antioxidants 3-6 were designed by combining the antioxidant features, namely, a benzoquinone fragment and a… Expand

The present article expands on the study of structure-activity relationships of the novel class of quinone-bearing polyamines, as… Expand

The initial transition of amyloid β (1–42) (Aβ42) soluble monomers/small oligomers from unordered/α‐helix to a β‐sheet‐rich… Expand

One of the characteristics of Alzheimer's disease (AD) that hinders the discovery of effective disease-modifying therapies is the… Expand