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meayamycin B

National Institutes of Health

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MorpholinesPyrans

Papers overview

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2020
2020
Total synthesis of meayamycin B.
Meayamycin B is currently the most potent modulator of the splicing factor 3b subunit 1 and used by dozens of research groups… 
2019
2019
Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma
Introduction Therapeutic options for diffuse malignant peritoneal mesothelioma (DMPM) are limited to surgery and locoregional… 
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2015
2015
An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses
Adeno-associated viruses (AAV) have evolved to exploit the dynamic reorganization of host cell machinery during co-infection by… 
2014
2014
Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells
ABT-737 inhibits the anti-apoptotic proteins B-cell lymphoma 2 (BCL-2) and BCL-XL. Meayamycin B switches the splicing pattern of… 
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2014
2014
Spliceosome Inhibitor Meayamycin B As a Novel Potential Chemotherapeutic Agent in ALL and AML
Introduction The process of pre-mRNA splicing is gaining attention as a contributor to anticancer drug resistance and as a… 
2014
2014
Regulation of HPV 16 E 6 and MCL 1 by SF 3 B 1 inhibitor in head and neck cancer cells
ABT-737 inhibits the anti-apoptotic proteins B-cell lymphoma 2 (BCL-2) and BCL-XL. Meayamycin B switches the splicing pattern of… 
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Highly Cited
2013
Highly Cited
2013
Chemical perturbation of Mcl-1 pre-mRNA splicing to induce apoptosis in cancer cells.
The myeloid cell leukemia-1 (MCL1) gene encodes antiapoptotic Mcl-1(L) and proapoptotic Mcl-1(S) proteins. In cancer, the Mcl-1(L… 
2013
2013
Abstract 2064: SF3B1 inhibitors sensitize head and neck squamous cell carcinoma to Bcl-xL inhibition by regulating Mcl-1 alternative splicing.
This study explored the application of the alternative splicing of Bcl-2 family protein Mcl-1 in combination chemotherapy for… 
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