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lymphoid enhancer-binding factor 1

Known as: Lymphoid Enhancer-Binding Factor 1 [Chemical/Ingredient], Transcription Factor, LEF-1, T Cell Specific Transcription Factor 1 alpha 
Lymphoid enhancer-binding factor 1 (399 aa, ~44 kDa) is encoded by the human LEF1 gene. This protein is involved in Wnt signaling and transcriptional… 
National Institutes of Health

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Beta-Catenin Accumulation PathwayCell Differentiation processCell Proliferation Regulatory ProcessChemotaxis

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Lef1 protein, mouse

Papers overview

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Highly Cited
2012
Highly Cited
2012
miR-449a regulates the chondrogenesis of human mesenchymal stem cells through direct targeting of lymphoid enhancer-binding factor-1.
microRNAs are small molecules, about 17-23 nucleotides in length, that act as translational regulators of their target gene. By… 
2006
2006
Functional interactions between Dlx2 and lymphoid enhancer factor regulate Msx2
Dlx2, Lymphoid Enhancer Factor (Lef-1) and Msx2 transcription factors are required for several developmental processes. To… 
2006
2006
Variation of LEF-1 mRNA expression in low-grade B-cell non-Hodgkin's lymphoma.
2006
2006
Morphological, phylogenetic and biological characteristics of Ectropis obliqua single-nucleocapsid nucleopolyhedrovirus.
The tea looper caterpillar, Ectropis obliqua, is one of the major pests of tea bushes. E. obliqua single-nucleocapsid… 
2005
2005
Alterations of lymphoid enhancer factor-1 isoform expression in solid tumors and acute leukemias.
Two major transcripts of lymphoid enhancer factor-1 (LEF-1) have been described. The long isoform with b-catenin binding domain… 
2004
2004
Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor α Regulation of ELA2*
Two hereditary human leukemia syndromes are severe congenital neutropenia (SCN), caused by mutations in the gene ELA2, encoding… 
Highly Cited
2003
Highly Cited
2003
Synergistic cooperation between the AP‐1 and LEF‐1 transcription factors in the activation of the matrilysin promoter by the src oncogene: implications in cellular invasion
The matrix metalloprotease matrilysin is expressed in premalignant polyps and plays a key role in local invasion during the… 
2002
2002
Lymphoid Enhancer Factor-1 Blocks Adenomatous Polyposis Coli-mediated Nuclear Export and Degradation of β-Catenin
The oncogenic protein β-catenin is overexpressed in many cancers, frequently accumulating in nuclei where it forms active… 
Highly Cited
2001
Highly Cited
2001
Involvement of Wnt signaling pathway in murine medulloblastoma induced by human neurotropic JC virus
By using the early genome of the human neurotropic polyomavirus, JCV, we have created transgenic animals that develop cerebellar… 
Review
1993
Review
1993
Transcriptional regulation of T cell receptor genes.
The diverse lineages of the mammalian hematopoietic system including both B and T lymphocytes are derived from a single… 
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