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loxtidine

 
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
BACKGROUND & AIMS Apart from its importance as an acid secretogogue, the role of histamine as a downstream target of gastrin has… Expand
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2004
2004
Spontaneously hypergastrinemic cotton rats (Sigmodon hispidus) develop tumors that have the phenotype of an adenocarcinoma but… Expand
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Highly Cited
2001
Highly Cited
2001
The in vivo metabolism of three pharmaceutical compounds, EMD68843, EMD96785, and EMD128130, was compared in fresh and… Expand
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Highly Cited
1999
Highly Cited
1999
1. The metabolism of loxtidine (1-methyl-5-[3-[3-[(1-piperidinyl) methyl] phenoxy] propyl] amino-1H-1,2,4-triazole-3-methanol… Expand
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Highly Cited
1993
Highly Cited
1993
The effect of the selective H3 receptor agonist (R)-alpha-methylhistamine and antagonist thioperamide on water consumption in the… Expand
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1990
1990
involved incubations for a standard period of 32 h. Data in Fig. l ( b ) indicate that the production rate of IGF-1 was sensitive… Expand
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1988
1988
Loxtidine, a potent, non-competitive histamine H2-receptor antagonist was evaluated for genotoxic potential using a range of… Expand
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Highly Cited
1986
Highly Cited
1986
The oral administration of loxtidine to mice at doses of 600, 250, and 50 mg/kg/day for 746 days produced carcinoid tumours of… Expand
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Highly Cited
1985
Highly Cited
1985
1 The very late occurrence of gastric carcinoids in a life‐span carcinogenicity study with loxtidine in the rat might have… Expand
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Highly Cited
1985
Highly Cited
1985
The oral administration of loxtidine, a potent histamine H2-antagonist, to a total of 378 rats at doses of 50, 185, or 685 mg/kg… Expand
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