lomitapide

Known as: 9H-Fluorene-9-Carboxamide, N-(2,2,2-Trifluoroethyl)-9-(4-(4-(((4'-(Trifluoromethyl)(1,1'-Biphenyl)-2-yl)Carbonyl)Amino)-1-Piperidinyl)Butyl)-, N-(2,2,2-Trifluoroethyl)-9-(4-(4-(((4'-(Trifluoromethyl)Biphenyl-2-yl)Carbonyl)Amino)Piperidin-1-yl)Butyl)-9H-Fluorene-9-Carboxamide 
A small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
AIM There is an unmet need in Japan for more optimal lipid-lowering therapy (LLT) for patients with homozygous familial… (More)
  • table 1
  • table 2
  • table 3
Is this relevant?
2016
2016
BACKGROUND Lomitapide is an orally active selective inhibitor of microsomal triglyceride transfer protein approved as adjunctive… (More)
Is this relevant?
2016
2016
BACKGROUND Lomitapide reduces low-density lipoprotein-cholesterol (LDL-C) but also high-density lipoprotein-cholesterol (HDL-C… (More)
  • table 1
  • figure 1
Is this relevant?
2015
2015
Homozygous familial hypercholesterolaemia (HoFH) is a rare genetic disease characterised by markedly elevated plasma levels of… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • table 3
Is this relevant?
Review
2014
Review
2014
1022 L ow-density lipoproteins (LDLs) are a proven causal risk factor for the development of atherosclerotic cardiovascu-lar… (More)
  • figure 1
  • figure 2
Is this relevant?
2014
2014
IMPORTANCE Recurrent pancreatitis is a potentially fatal complication of severe hypertriglyceridemia. Genetic defects and… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Review
2014
Review
2014
Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder of low-density lipoprotein cholesterol (LDL-C… (More)
Is this relevant?
Review
2014
Review
2014
The microsomal triglyceride transfer protein (MTP) inhibitor lomitapide is a licenced adjunct to a low-fat diet and other lipid… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2013
Highly Cited
2013
BACKGROUND Patients with homozygous familial hypercholesterolaemia respond inadequately to existing drugs. We aimed to assess the… (More)
Is this relevant?
Review
2010
Review
2010
New lipid-lowering agents include microsomal triglyceride transfer protein (MTP) inhibitors, which may have a role in the… (More)
Is this relevant?