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lipoate metabolic process

Known as: lipoate metabolism, lipoic acid metabolic process, lipoic acid metabolism 
The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. [GOC:ai, ISBN:0198506732]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2016
012319702016

Papers overview

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2014
2014
Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes.
Cofactor disorders of mitochondrial energy metabolism are a heterogeneous group of diseases with a wide variety of clinical… (More)
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2009
2009
Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase.
Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covalent ligation of lipoic acid onto specific lysine side… (More)
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2009
2009
Opening a new path to lipoic acid.
Lipoic acid (Fig. 1) is a cofactor that is critical to the catalytic function of several key enzymes in intermediary metabolism… (More)
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2009
2009
Lipoic acid synthesis and attachment in yeast mitochondria.
Lipoic acid is a sulfur-containing cofactor required for the function of several multienzyme complexes involved in the oxidative… (More)
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2005
2005
Function, attachment and synthesis of lipoic acid in Escherichia coli.
A series of genetic, biochemical, and physiological studies in Escherichia coli have elucidated the unusual pathway whereby… (More)
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1997
1997
Cloning and transcriptional analysis of the lipA (lipoic acid synthetase) gene from Rhizobium etli.
We report here the isolation of a Rhizobium etli gene involved in lipoic acid metabolism, the lipA gene, which complements a lipA… (More)
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1994
1994
Mutants of Escherichia coli K-12 that are resistant to a selenium analog of lipoic acid identify unknown genes in lipoate metabolism.
Lipoic acid is a disulfide-containing cofactor required for the reactions catalyzed by alpha-ketoacid dehydrogenase enzyme… (More)
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1993
1993
Lipoic acid metabolism in Escherichia coli: sequencing and functional characterization of the lipA and lipB genes.
Two genes, lipA and lipB, involved in lipoic acid biosynthesis or metabolism were characterized by DNA sequence analysis. The… (More)
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1993
1993
Isolation and characterization of LIP5. A lipoate biosynthetic locus of Saccharomyces cerevisiae.
A number of mutants with pleiotropic effects on mitochondrial metabolism have been isolated in yeast Saccharomyces cerevisiae… (More)
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1970
1970
Necrotizing encephalomyelopathy of Leigh. Neuropathological findings in 8 cases.
 
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