lidorestat

Known as: 3-((4,5,7-Triflurobenzothiazol-2-yl)methyl)-1H-indol-1-yl-acetic Acid, 3-((4,5,7-trifluorobenzothiazol-2-yl)methyl)indole-N-acetic acid 
 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

EML 676

Broader (2)

Indoleacetic AcidsThiazoles

Papers overview

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2019
2019
Base promoted synthesis of novel indole-dithiocarbamate compounds as potential anti-inflammatory therapeutic agents for treatment of acute lung injury.
An efficient protocol for highly chemoselective introduction of dithiocarbamate groups to nitrogen position of indoles with bis… (More)
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2015
2015
Synthesis and pharmacological evaluation of a novel AT1 angiotensin II receptor antagonist with anti-hypertension and anti-tumor effects.
A new compound 2-(4-((2-butyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl) benzamide (1) was designed, synthesized and… (More)
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Review
2015
Review
2015
Updates on Aldose Reductase Inhibitors for Management of Diabetic Complications and Non-diabetic Diseases.
Diabetes mellitus occurrence has been associated to the modification of the physiological levels of glucose and is often… (More)
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2014
2014
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF CERTAIN NOVEL MANNICH BASES CONTAINING INDOLE MOIETY LINKED WITH THIONE POSSESSING AZETIDINE-4-ONE, THIAZOLIDINE-2-ONE AND TETRAZOLES
The article is aimed to synthesize, characterize and screening the biological activity of a series of N-((3-(4-chloro-3oxo-1-((4… (More)
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2013
2013
RATIONAL DESIGN AND SYNTHESIS OF SOME NOVEL SUBSTITUTED ACETAMIDES BEARING 2-(3-ACETYL-(1H- INDOL-1-YL/5-METHOXY-1H-INDOL-1-YL)) MOTIFS AND THEIR STUDY FOR ACETYLCHOLINESTERASE INHIBITORY ACTIVITY
INTRODUCTION Many thousands of people are suffering from Alzheimer’s disease (AD) and the number may double in another decade. It… (More)
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2012
2012
Synthesis, anti-hypertensive effect of a novel angiotensin II AT1 receptor antagonist and its anti-tumor activity in prostate cancer.
Since the first non-peptide Ang II receptor antagonist was originally reported, it has become the most common target in the… (More)
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2011
2011
Synthesis of Some Heterocyclic Compounds Derived from 1,3- dihydro-2H-indol-2-one
In this work (2-oxo-2,3-dihydro-1H-indol-1-yl)Acetic acid was prepared from (1,3-dihydro-2H-indol-2-one) with chloro acetic acid… (More)
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2009
2009
Regulation of plasma fructose and mortality in mice by the aldose reductase inhibitor lidorestat.
Aldose reductase (AR), an enzyme widely believed to be involved in the aberrant metabolism of glucose and development of diabetic… (More)
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2008
2008
Nouveaux derives d'1h-indol-1-yl uree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
 
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2005
2005
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic…
Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of… (More)
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