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largazole

National Institutes of Health

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Broader (2)

DepsipeptidesThiazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Synthesis of a New Pyridine Pharmaceutical Intermediate in Potential Anti-cancer o f
In order to obtain better anti-cancer activity of HDACI, new HDCIs analog and a pyridine pharmaceutical intermediate were… 
2015
2015
AWARD NUMBER: W81XWH-10-1-0990 TITLE: Largazole as a Novel and Selective Anti-Breast Cancer Agent PRINCIPAL INVESTIGATOR:
Protein ubiquitination plays an important role in the regulation of almost every aspect of eukaryotic cellular function… 
2015
2015
Largazole Analogues as Histone Deacetylase Inhibitors : Synthesis and Biological Evaluation
A. Al-Hamashi, J. Almaliti, R. Farrell, V. L. Tillekeratne University of Toledo Purpose Histone deacetylase (HDAC) enzymes, which… 
2015
2015
The role of histone deacetylase inhibitor largazole in anti-aging of hUCMSCs
Objective This research adopt the histone acetylation inhibitor largazole to treat on human umbilical cord mesenchymal stem cells… 
2014
2014
Design and synthesis of mono and bicyclic tetrapeptides thioester as potent inhibitor of histone deacetylases
Inhibitors of histone deacetylases (HDACs) are a promising class of anticancer agents that have an effect on gene regulation. The… 
2012
2012
latent EBV and sensitize lymphoma cells to nucleoside antiviral agents Histone deacetylase inhibitors are potent inducers of gene expression in
http://bloodjournal.hematologylibrary.org/content/119/4/1008.full.html Updated information and services can be found at: (1291… 
2012
2012
Title: Largazole as a Novel and Selective Anti-breast Cancer Agent Principal Investigator: Largazole as a Novel and Selective Anti-breast Cancer Agent Approved for Public Release; Distribution…
Protein ubiquitination plays an important role in the regulation of almost every aspect of eukaryotic cellular function… 
2012
2012
Concise synthesis of the thiazole-thiazoline fragment of largazole
2011
2011
Histone deacetylases (HDACs) and histone acetylases (HATs) are key players in regulating transcription and histone homeostasis(8). Transcription of tumor suppressor proteins is frequently silenced in…
2010
2010
I.Total Syntheses and Biological Studies of Largazole and Brasilibactin A. II.Stereoselective Synthesis of 2,6-Cis- and 2,6-Trans-Piperidines through an Organocatalytic Aza-Michael Reaction.
The dissertation focuses on three main projects which complement the studies towards the total syntheses of biologically active… 
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