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largazole

National Institutes of Health

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DepsipeptidesThiazoles

Papers overview

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2020
2020
Corrigendum to "A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling" [Eur. J. Med. Chem. 182 (2019) 111672].
Review
2016
Review
2016
Potential therapeutic targets and the role of technology in developing novel cannabinoid drugs from cyanobacteria.
2015
2015
Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostere
PurposeLargazole is a potent class I-selective HDACi natural product isolated from the marine cyanobacteria Symploca sp. The… 
2015
2015
Largazole Analogues as Histone Deacetylase Inhibitors : Synthesis and Biological Evaluation
A. Al-Hamashi, J. Almaliti, R. Farrell, V. L. Tillekeratne University of Toledo Purpose Histone deacetylase (HDAC) enzymes, which… 
2012
2012
latent EBV and sensitize lymphoma cells to nucleoside antiviral agents Histone deacetylase inhibitors are potent inducers of gene expression in
http://bloodjournal.hematologylibrary.org/content/119/4/1008.full.html Updated information and services can be found at: (1291… 
2012
2012
Title: Largazole as a Novel and Selective Anti-breast Cancer Agent Principal Investigator: Largazole as a Novel and Selective Anti-breast Cancer Agent Approved for Public Release; Distribution…
Protein ubiquitination plays an important role in the regulation of almost every aspect of eukaryotic cellular function… 
2011
2011
Synthesis of the thiazole-thiazoline fragment of largazole analogues.
The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been… 
2011
2011
Histone deacetylases (HDACs) and histone acetylases (HATs) are key players in regulating transcription and histone homeostasis(8). Transcription of tumor suppressor proteins is frequently silenced in…
2010
2010
Histone Deacetylase Inhibitors: Potent Inducers of Tumor Latent EBV Thymidine Kinase Induction
Abstract 1831 Strong epidemiological association of Epstein-Barr Virus (EBV) with various human lymphoid malignancies and in… 
2009
2009
Largazole, a Novel Cyclic Peptide Histone Deacetylase Inhibitor, Demonstrates Anti-MM Effects Alone and Increases the Anti-MM Effects of Bortezomib.
Abstract 4925 Multiple myeloma (MM) remains an incurable malignancy. Therefore, there is a need for the development of new agents… 
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