lactonamycin
National Institutes of Health
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The Bull-Hutchings-Quayle (BHQ) reaction is a novel method for the synthesis of 1-(bromo/chloro)napthalenes from 2-allyphenyl-2…
Work was undertaken towards the synthesis of the promising antibiotic lactonamycin (iii). Following the work of Parsons et al. it…
The discovery of the novel thermal cyclization of enediyne molecules within the
Parsons group during studies directed towards…
The lactonamycin model aglycon 4 was synthesized from the trihalogenated benzene derivative 10. Ethynyltetraol 6 was prepared…
A novel cascade reaction has been developed for the rapid construction of heterocyclic rings. The cyclization is thermally…
Model studies on the synthesis of the tetracyclic ABCD ring system of lactonamycin (1) are described. The key step involved the…
[reaction: see text] An enantiospecific synthesis of the AB fragment of lactonamycin (5) is achieved in eight steps from dimethyl…
An efficient synthesis of the ABCD-ring system of lactonamycin (1) is reported in this Letter. The key step is the tandem cyanide…
[reaction: see text]. A synthesis of the CDEF fragment of lactonamycin is achieved in eight steps (six pots) from the known and…
[reaction: see text]. In this Letter, we describe an approach to the highly functionalized tetracycle 6, a model compound…