FAQ

lactic acid secretion

Known as: lactate secretion 
The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue. [GOC:ai]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2018
0102019672018

Papers overview

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2014
2014
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.
JMJD5, a Jumonji C domain-containing dioxygenase, is important for embryonic development and cancer growth. Here, we show that… (More)
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Highly Cited
2013
Highly Cited
2013
Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
Mammalian cells can generate ATP via glycolysis or mitochondrial respiration. Oncogene activation and hypoxia promote glycolysis… (More)
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2013
2013
Optical metabolic imaging identifies glycolytic levels, subtypes, and early-treatment response in breast cancer.
Abnormal cellular metabolism is a hallmark of cancer, yet there is an absence of quantitative methods to dynamically image this… (More)
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Highly Cited
2011
Highly Cited
2011
Genome-Scale Metabolic Modeling Elucidates the Role of Proliferative Adaptation in Causing the Warburg Effect
The Warburg effect--a classical hallmark of cancer metabolism--is a counter-intuitive phenomenon in which rapidly proliferating… (More)
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Highly Cited
2011
Highly Cited
2011
Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo
Tumor cells exhibit an altered metabolism characterized by elevated aerobic glycolysis and lactate secretion which is supported… (More)
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2011
2011
MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells
MicroRNAs (miRNAs) are well recognized as gene regulators and have been implicated in the regulation of development as well as… (More)
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2011
2011
Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes
INTRODUCTION In the human brain, there are at least as many astrocytes as neurons. Astrocytes are known to modulate neuronal… (More)
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Highly Cited
2009
Highly Cited
2009
GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis.
Accelerated glycolysis is one of the biochemical characteristics of cancer cells. The glucose transporter isoform 1 (GLUT1) gene… (More)
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Highly Cited
2009
Highly Cited
2009
Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells.
Interactions of hyaluronan with CD44 in tumor cells play important cooperative roles in various aspects of malignancy and drug… (More)
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2004
2004
Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy.
The lipodystrophy syndrome (adipose tissue redistribution and metabolic abnormalities) observed with highly active antiretroviral… (More)
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