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lactic acid secretion

Known as: lactate secretion 
The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue. [GOC:ai]
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease
Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause of cognitive impairment. Due to… Expand
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Highly Cited
2015
Highly Cited
2015
Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs
To elucidate the little-known bioenergetic pathways of host immune cells in tuberculosis, a granulomatous disease caused by the… Expand
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Highly Cited
2014
Highly Cited
2014
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.
JMJD5, a Jumonji C domain-containing dioxygenase, is important for embryonic development and cancer growth. Here, we show that… Expand
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Highly Cited
2013
Highly Cited
2013
Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
Mammalian cells can generate ATP via glycolysis or mitochondrial respiration. Oncogene activation and hypoxia promote glycolysis… Expand
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Review
2013
Review
2013
Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?
The common preference of cancers for lactic acid-generating metabolic energy pathways has led to proposals that their… Expand
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Highly Cited
2012
Highly Cited
2012
Effect of insulin deprivation on metabolism and metabolism-associated gene transcript levels of in vitro cultured human Sertoli cells.
BACKGROUND Sertoli cells metabolize glucose producing lactate for developing germ cells. As insulin regulates glucose uptake and… Expand
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Highly Cited
2011
Highly Cited
2011
Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo
Tumor cells exhibit an altered metabolism characterized by elevated aerobic glycolysis and lactate secretion which is supported… Expand
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Highly Cited
2011
Highly Cited
2011
Genome-Scale Metabolic Modeling Elucidates the Role of Proliferative Adaptation in Causing the Warburg Effect
The Warburg effect--a classical hallmark of cancer metabolism--is a counter-intuitive phenomenon in which rapidly proliferating… Expand
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Highly Cited
2011
Highly Cited
2011
MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells
BackgroundMicroRNAs (miRNAs) are well recognized as gene regulators and have been implicated in the regulation of development as… Expand
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Highly Cited
2009
Highly Cited
2009
GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis.
Accelerated glycolysis is one of the biochemical characteristics of cancer cells. The glucose transporter isoform 1 (GLUT1) gene… Expand
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