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ketol-acid reductoisomerase activity

Known as: (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing), 2-hydroxy-3-keto acid reductoisomerase activity, dihydroxyisovalerate dehydrogenase (isomerizing) activity 
Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. [EC:1.1.1.86]
National Institutes of Health

Papers overview

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2019
2019
Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb
BackgroundNothapodytes nimmoniana, a plant of pivotal medicinal significance is a source of potent anticancer monoterpene indole… Expand
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2018
2018
Steroid Degradation in Comamonas testosteroni TA441: Identification of Metabolites and the Genes Involved in the Reactions Necessary before D-Ring Cleavage.
Bacterial steroid degradation has been studied mainly with Rhodococcus equi (Nocardia restrictus) and Comamonas testosteroni as… Expand
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2015
2015
Flavonoids: true or promiscuous inhibitors of enzyme? The case of deoxyxylulose phosphate reductoisomerase.
Flavonoids, due to their physical and chemical properties (among them hydrophobicity and metal chelation abilities), are… Expand
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2013
2013
DXP reductoisomerase: reaction of the substrate in pieces reveals a catalytic role for the nonreacting phosphodianion group.
The role of the nonreacting phosphodianion group of 1-deoxy-d-xylulose-5-phosphate (DXP) in catalysis by DXP reductoisomerase… Expand
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2013
2013
Isomerizing ethenolysis as an efficient strategy for styrene synthesis.
A shrinking chain: A bimetallic system consisting of [{Pd(μ-Br)(tBu3P)}2] and a ruthenium metathesis catalyst has been found to… Expand
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2012
2012
Isomerizing olefin metathesis as a strategy to access defined distributions of unsaturated compounds from fatty acids.
The dimeric palladium(I) complex [Pd(μ-Br)(t)Bu(3)P](2) was found to possess unique activity for the catalytic double-bond… Expand
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2004
2004
Inhibition of isoprene biosynthesis pathway enzymes by phosphonates, bisphosphonates, and diphosphates.
We have investigated the docking of a variety of inhibitors and substrates to the isoprene biosynthesis pathway enzymes farnesyl… Expand
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2000
2000
Plasmodium falciparum: detection of the deoxyxylulose 5-phosphate reductoisomerase activity.
Wiesner, J., Hintz, M., Altincicek, B., Sanderbrand, S., Weidemeyer, C., Beck, E., and Jomaa, H. 2000. Plasmodium falciparum… Expand
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1992
1992
Isolation and kinetic properties of acetohydroxy acid isomeroreductase from spinach (Spinacia oleracea) chloroplasts overexpressed in Escherichia coli.
Acetohydroxy acid isomeroreductase catalyses a two-step reaction, an alkyl migration and a NADPH-dependent reduction, in the… Expand
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1973
1973
Isoleucine and valine metabolism in Escherichia coli. XXII. A pleiotropic mutation affecting induction of isomeroreductase activity.
The ilvC gene product, acetohydroxy acid isomeroreductase, an enzyme essential for isoleucine and valine formation, is subject to… Expand
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