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ketol-acid reductoisomerase activity

Known as: (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing), 2-hydroxy-3-keto acid reductoisomerase activity, dihydroxyisovalerate dehydrogenase (isomerizing) activity 
Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. [EC:1.1.1.86]
National Institutes of Health

Papers overview

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2019
2019
Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb
BackgroundNothapodytes nimmoniana, a plant of pivotal medicinal significance is a source of potent anticancer monoterpene indole… 
2018
2018
Steroid Degradation in Comamonas testosteroni TA441: Identification of Metabolites and the Genes Involved in the Reactions Necessary before D-Ring Cleavage
Studies on representative steroid degradation bacteria Rhodococcus equi (Nocardia restrictus) and Comamonas testosteroni were… 
2015
2015
Flavonoids: true or promiscuous inhibitors of enzyme? The case of deoxyxylulose phosphate reductoisomerase.
2013
2013
Isomerizing ethenolysis as an efficient strategy for styrene synthesis.
A shrinking chain: A bimetallic system consisting of [{Pd(μ-Br)(tBu3P)}2] and a ruthenium metathesis catalyst has been found to… 
2013
2013
DXP reductoisomerase: reaction of the substrate in pieces reveals a catalytic role for the nonreacting phosphodianion group.
The role of the nonreacting phosphodianion group of 1-deoxy-d-xylulose-5-phosphate (DXP) in catalysis by DXP reductoisomerase… 
Highly Cited
2012
Highly Cited
2012
Isomerizing olefin metathesis as a strategy to access defined distributions of unsaturated compounds from fatty acids.
The dimeric palladium(I) complex [Pd(μ-Br)(t)Bu(3)P](2) was found to possess unique activity for the catalytic double-bond… 
2004
2004
Inhibition of isoprene biosynthesis pathway enzymes by phosphonates, bisphosphonates, and diphosphates.
We have investigated the docking of a variety of inhibitors and substrates to the isoprene biosynthesis pathway enzymes farnesyl… 
2000
2000
Plasmodium falciparum: detection of the deoxyxylulose 5-phosphate reductoisomerase activity.
Abstract Wiesner, J., Hintz, M., Altincicek, B., Sanderbrand, S., Weidemeyer, C., Beck, E., and Jomaa, H. 2000. Plasmodium… 
1992
1992
Isolation and kinetic properties of acetohydroxy acid isomeroreductase from spinach (Spinacia oleracea) chloroplasts overexpressed in Escherichia coli.
Acetohydroxy acid isomeroreductase catalyses a two-step reaction, an alkyl migration and a NADPH-dependent reduction, in the… 
1973
1973
Isoleucine and Valine Metabolism in Escherichia coli XXII. A Pleiotropic Mutation Affecting Induction of Isomeroreductase Activity
The ilvC gene product, acetohydroxy acid isomeroreductase, an enzyme essential for isoleucine and valine formation, is subject to… 
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