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kahalalide F

National Institutes of Health

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Depsipeptides

Papers overview

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2010
2010
Iron Complexation to Oxygen Rich Marine Natural Products: A Computational Study
The natural products kahalalide F, halichondrin B, and discodermolide are relatively large structures that were originally… 
2005
2005
Clinical and pharmacokinetic phase I dose-finding study of kahalalide F (KF) administered as a prolonged infusion in patients with solid tumors
2059 Background: KF is a cytotoxic cyclic peptide derived from the mollusc Elysia rufescens. Two prior phase 1 studies assessed 1… 
2004
2004
Phase I and pharmacokinetic study of Kahalalide F in patients with advanced androgen refractory prostate cancer.
2076 Introduction: Kahalalide F (KF) is one of a family of novel dehydroaminobutyric acid-containing peptides isolated from the… 
2004
2004
560 Kahalalide F (KF) induces apoptosis-independent cell death that involves ErbB3 downregulation and inhibition of Akt signalling
2003
2003
572 Kahalalide F (KF), a new marine compound, in vitro radiosensitizes human tumoral cell lines
2003
2003
549 Liver toxicity: a predictable and manageable toxicity for kahalalide F (KF)
2002
2002
Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray ionization tandem…
Kahalalide F (KF) is a novel cyclic depsipeptide anticancer drug, which has shown anticancer activity both in vitro and in vivo… 
2002
2002
Preclinical toxicity studies of kahalalide F, a new anticancer agent: single and multiple dosing regimens in the rat
HeadingAbstractPurpose. Kahalalide F (KF) is a new anticancer agent currently in clinical trials for solid tumors, including… 
2001
2001
Development of a Lyophilized Parenteral Pharmaceutical Formulation of the Investigational Polypeptide Marine Anticancer Agent Kahalalide F
Kahalalide F is a novel antitumor agent isolated from the marine mollusk Elysia rufescens; it has shown highly selective in vitro… 
2001
2001
In vitro hemolysis and buffer capacity studies with the novel marine anticancer agent kahalalide F and its reconstitution vehicle cremophor EL/ethanol.
An in vitro biocompatibility study was performed with the pharmaceutical formulation of the investigational, marine-derived… 
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