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itazigrel

Known as: 4,5-BMTT, 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)thiazole, 4,5-Bis(4-methoxyphenyl)-2-trifluoromethylthiazole 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Thiazoles

Narrower (1)

U 53059

Papers overview

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1994
1994
Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles.
The syntheses, biological evaluations, and structure-activity relationships of a series of 4,5-bis-(4-methoxyphenyl)-2… 
1994
1994
Enhanced rectal absorption of itazigrel formulated with polysorbate 80 micelle vehicle in rat: role of co‐administered esterase
Abstract— We investigated the effect of esterase on rectal absorption in the rat of itazigrel using polysorbate 80 (PS‐80… 
1994
1994
Pharmacokinetics and cyclooxygenase inhibition of itazigrel in normal volunteers after single oral doses.
The pharmacokinetics and cyclooxygenase inhibition of itazigrel were studied in normal male volunteers. In a low-dose study… 
1993
1993
Use of Enzymatic Activity for Design of Orally Administered Enteric Dosing Forms
Abstract— Liquid and semi‐solid enteric dosage forms were prepared by entrapping drug with an appropriate partition coefficient… 
1990
1990
Simple, rapid and sensitive high-performance liquid chromatographic procedure for the quantitation of itazigrel in human plasma or serum.
1989
1989
Quantitative determination of itazigrel in rodent diet by reversed-phase HPLC and evaluation of its stability at 20 degrees C.
A simple, accurate and precise procedure for the quantitation of itazigrel (a potent lipophilic inhibitor of collagen and… 
1987
1987
The Effect of Itazigrel and Aspirin on the Mucosa of the Esophagus, Stomach, and Duodenum of Normal Subjects
The effects of aspirin, itazigrel (U‐53,059; a new antiplatelet drug), and placebo on the mucosa of the esophagus, stomach, and… 
1981
1981
Synthesis and platelet aggregation inhibitory activity of 4,5-bis(aryl)-2-substituted-thiazoles.
In our continuing effort to discover compound which inhibit collagen-induced platelet aggregation, we have screened compounds in… 
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