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isothiazole

 
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Tip60 (KAT5) is a histone acetyltransferase (HAT enzyme) involved in multiple cellular processes including transcriptional… Expand
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2012
2012
The disclosed 3-phenyl-5-isothiazole carboxamides are potent allosteric antagonists of mGluR1 with generally good selectivity… Expand
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2012
2012
MEK-1 and MEK-2 are dual-specificity kinases and important components in the mitogen-activated protein kinase pathway. These… Expand
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2010
2010
In this study, quantitative structure-activity/property models are developed for modeling and predicting both MEK inhibitory… Expand
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Highly Cited
2010
Highly Cited
2010
A series of novel 1,3,4-oxadiazole derivatives based on structural and electronic overlap with combretastatins have been designed… Expand
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2009
2009
Reaction between 4-formyl-2-methoxyphenyl 4,5-dichloroisothiazole-3-carboxylate with various aromatic amines led to azomethins 2… Expand
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2006
2006
Isothiazole analogs were discovered as a novel class of active-site inhibitors of HCV NS5B polymerase. The best compound has an… Expand
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2006
2006
Regioselective palladium catalysed coupling reactions are achieved in good to high yields, starting from either 3,5-dichloro- or… Expand
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2006
2006
The design, synthesis, and biological evaluation of potent inhibitors of the TrkA kinase is presented. A homology model is… Expand
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Highly Cited
2003
Highly Cited
2003
Signaling through vascular endothelial growth factor (VEGF) receptors (VEGFRs) is a key pathway initiating endothelial cell… Expand
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