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isothiazole

National Institutes of Health

Papers overview

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2018
2018
Cascade Trisulfur Radical Anion (S3•-) Addition/Electron Detosylation Process for the Synthesis of 1,2,3-Thiadiazoles and Isothiazoles.
Trisulfur radical anion (S3•-) mediated reactions with in situ formed azoalkenes and α,β-usaturated N-sulfonylimines for the… 
2014
2014
Docking and Quantitative Structure Activity Relationship studies of Acyl Guanidines as β-Secretase (BACE1) Inhibitor
β-Secretase (beta-amyloid converting enzyme 1 [BACE1]) is involved in the first and rate-limiting step of βamyloid (Aβ) peptides… 
2011
2011
Identification and characterization of inhibitors of Haemophilus influenzae acetohydroxyacid synthase.
2007
2007
Synthesis of stable isothiazole carbenes.
Whereas stable imi-dazolyl-2- and 1,3-thiazol-2-ylidenes are accessible, isothia-zol-3-ylidenes4 could not beisolated until now… 
2005
2005
Antipoliovirus activity of isothiazole derivatives: mode of action of 5,5′-diphenyl-3,3′-diisothiazole disulfide (DID)
SummaryIn this report we describe the antiviral activity of 5,5′-diphenyl-3,3′-diisothiazole disulfide (DID) and discuss its mode… 
2004
2004
Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.
2003
2003
Novel synthesis and reactions of 5,7-dialkyl-4,6-dioxo-4,5,6,7-tetrahydro- isothiazolo[3,4,-d]pyrimidine-3-carbonitriles and 6-methyl-4-oxo-4H-1-aza-5-oxa-2- thiaindene-3-carbonitrile.
[reaction: see text] 5,7-Dialkyl-4,6-dioxo-4,5,6,7-tetrahydroisothiazolo[3,4-d]pyrimidine-3-carbonitriles 4, prepared from 6… 
2002
2002
Synthesis of new 3-methylthio-5-aryl-4-isothiazolecarbonitriles with broad antiviral spectrum.
2000
2000
Anti-rhinovirus activity of 3-methylthio-5-aryl-4-isothiazolecarbonitrile derivatives.
1992
1992
Synthesis of isothiazole derivatives with potential biological activity.
The synthesis of acyl and ureido derivatives of substituted amides of 3-methyl-5-aminoisothiazole-4-carboxylic acid is presented… 
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