isomazole
National Institutes of Health
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1. Non-invasive measurements of blood pressure (BP) are method-specific estimates of actual blood pressure. The agreement of the…
Ventricular arrhythmias and disturbed auto-nomic control, as reflected by abnormal heart rate variability (HRV), are related to…
A 50-mg dose containing 50 µCi 14C-isomazole was administered orally to five healthy male volunteers. Blood, plasma, urine, feces…
The disposition of a new cardiotonic agent (isomazole (ISO)) was evaluated in healthy volunteers after various single oral (p.o…
A series of "A" ring substituted sulmazole and isomazole analogues have been prepared and evaluated as inotropic agents. pKA's…
Isomazole analogues which have achiral electron withdrawing substituents at the 4′‐position and analogues with heterocyclic ‘C…
1 The calcium sensitivity of force production of cardiac muscle fibres is altered by certain drugs. The sites of action of three…
Isomazole matrix tablet formulations, with various concentrations of hydroxypropyl methylcellulose (HPMC) hydrogel, were prepared…
Myocardial contractile force may be altered not only by changing intracellular free Ca2+ but also by increasing or decreasing the…