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isomazole

 
National Institutes of Health

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1 relation
sulmazole

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1994
1994
Activation of the sheep cardiac sarcoplasmic reticulum Ca2+‐release channel by analogues of sulmazole
1 The effect of sulmazole and several structurally related analogues on cardiac sarcoplasmic reticulum (SR) Ca2+‐release channel… Expand
1993
1993
Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase.
The synthesis and phosphodiesterase (PDE) inhibitory profile of a series of imidazopyridines, including sulmazole and isomazole… Expand
1991
1991
Effects of Isomazole on Force of Contraction and Phosphodiesterase Isoenzymes I‐IV in Nonfailing and Failing Human Hearts
The phosphodiesterase (PDE) inhibitor isomazole increased the force of contraction to 278.3 ± 89.1% (n = 7) of the predrug value… Expand
1990
1990
Inotropic "A" ring substituted sulmazole and isomazole analogues.
A series of "A" ring substituted sulmazole and isomazole analogues have been prepared and evaluated as inotropic agents. pKA's… Expand
1989
1989
Sustained release of isomazole from matrix tablets administered to dogs.
Isomazole matrix tablet formulations, with various concentrations of hydroxypropyl methylcellulose (HPMC) hydrogel, were prepared… Expand
1989
1989
Calcium-sensitivity modulation of cardiac myofibrillar proteins.
Myocardial contractile force may be altered not only by changing intracellular free Ca2+ but also by increasing or decreasing the… Expand
1989
1989
Toxicological evaluation of the cardiotonic isomazole in the dog.
Acute, subchronic, and chronic toxicity studies were conducted in dogs with the new vasodilator/cardiotonic drug isomazole (IMZ… Expand
1988
1988
Effect of isomazole on the responsiveness to calcium of the contractile elements in skinned cardiac muscle fibres of various species.
We report here that the new cardiotonic agent isomazole increases the Ca2+ responsiveness of skinned myocardial fibres from… Expand
Highly Cited
1987
Highly Cited
1987
In vitro vascular relaxation by new inotropic agents: relationship to phosphodiesterase inhibition and cyclic nucleotides.
Several novel cardiotonic vasodilators including bipyridines (amrinone and milrinone), imidazolones (enoximone and piroximone… Expand
1986
1986
Roles for Ca++ and cyclic AMP in mediating the cardiotonic actions of isomazole (LY175326).
The contractile state of cat papillary muscles was increased by isomazole in a concentration-dependent manner; inotropic effects… Expand
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