isomazole

1. The effect of sulmazole and several structurally related analogues on cardiac sarcoplasmic reticulum (SR) Ca(2+)-release… Expand

The phosphodiesterase (PDE) inhibitor isomazole increased the force of contraction to 278.3 +/- 89.1% (n = 7) of the predrug… Expand

Male and female Fischer 344 rats were treated with the positive inotropic agents, isomazole or indolidan, in the diet for 104… Expand

A series of "A" ring substituted sulmazole and isomazole analogues have been prepared and evaluated as inotropic agents. pKA's… Expand

Isomazole matrix tablet formulations, with various concentrations of hydroxypropyl methylcellulose (HPMC) hydrogel, were prepared… Expand

Acute, subchronic, and chronic toxicity studies were conducted in dogs with the new vasodilator/cardiotonic drug isomazole (IMZ… Expand

Myocardial contractile force may be altered not only by changing intracellular free Ca2+ but also by increasing or decreasing the… Expand

Acute, subchronic, and chronic toxicity studies were conducted with isomazole, a new (investigational) inotropic agent with… Expand

We report here that the new cardiotonic agent isomazole increases the Ca2+ responsiveness of skinned myocardial fibres from… Expand

Several novel cardiotonic vasodilators including bipyridines (amrinone and milrinone), imidazolones (enoximone and piroximone… Expand