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isoguanine

Known as: crotonoside, 2-OH-Ade, 2-hydroxyadenine 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Guanine

Papers overview

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Highly Cited
2006
Highly Cited
2006
Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1.
The MYH (MutY glycosylase homologue) increases replication fidelity by removing adenines or 2-hydroxyadenine misincorporated… 
Highly Cited
2003
Highly Cited
2003
First principles calculations of the pKa values and tautomers of isoguanine and xanthine.
The accurate replication of DNA requires the formation of complementary hydrogen bonds between a template base and the base… 
Highly Cited
2000
Highly Cited
2000
Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria
An enzyme activity introducing an alkali-labile site at 2-hydroxyadenine (2-OH-A) in double-stranded oligonucleotides was… 
Highly Cited
1999
Highly Cited
1999
Hypochlorous acid-induced DNA base modification: potentiation by nitrite: biomarkers of DNA damage by reactive oxygen species.
Chronic inflammation results in increased nitric oxide formation and nitrite (NO-2) accumulation. Activated phagocytes release… 
Highly Cited
1999
Highly Cited
1999
Effects of Ni(II) and Cu(II) on DNA interaction with the N-terminal sequence of human protamine P2: enhancement of binding and mediation of oxidative DNA strand scission and base damage.
Epidemiological evidence suggests that certain paternal exposures to metals may increase the risk of cancer in the progeny. This… 
Highly Cited
1997
Highly Cited
1997
Substitution and deletion mutations induced by 2-hydroxyadenine in Escherichia coli: effects of sequence contexts in leading and lagging strands.
To evaluate the mutation frequency and the mutation spectrum of 2-hydroxyadenine (2-OH-Ade), an oxidative DNA lesion, the… 
Highly Cited
1995
Highly Cited
1995
Formation of 2-Hydroxydeoxyadenosine Triphosphate, an Oxidatively Damaged Nucleotide, and Its Incorporation by DNA Polymerases
We found that hydroxylation occurs at the C-2 position of adenine by oxygen radical treatment (Fe-EDTA) of dA, dATP, and single… 
Highly Cited
1994
Highly Cited
1994
DNA base modifications in renal chromatin of wistar rats treated with a renal carcinogen, ferric nitrilotriacetate
Ferric nitrilotriacetate (Fe‐NTA) causes renal proximal tubular necrosis, a consequence of iron ion‐mediated free‐radical… 
Highly Cited
1992
Highly Cited
1992
Nickel(II)-mediated oxidative DNA base damage in renal and hepatic chromatin of pregnant rats and their fetuses. Possible relevance to carcinogenesis.
DNA base damage was studied in renal and hepatic chromatin of nickel(II)-injected pregnant female F344/NCr rats and their fetuses… 
Highly Cited
1976
Highly Cited
1976
Effects of adenosine analogs on rat cerebral cortical neurons.
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