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isogranulatimide

National Institutes of Health

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2 relations

Broader (2)

ImidazolesIndoles

Papers overview

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2015
2015
Kinase Inhibitor Profile for Human Nek1, Nek6, and Nek7 and Analysis of the Structural Basis for Inhibitor Specificity
Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential… Expand
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2014
2014
Design of granulatimide and isogranulatimide analogues as potential Chk1 inhibitors: Study of amino-platforms for their synthesis.
The two marine alkaloids granulatimide and isogranulatimide have been shown to inhibit the checkpoint kinase 1 (Chk1), a… Expand
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2012
2012
Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide.
A series of pyrrolic analogs and two series of regioisomeric pyrazolic analogs of the marine alkaloids granulatimide and… Expand
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2007
2007
Synthesis and biological activities of isogranulatimide analogues.
The synthesis of new isogranulatimide analogues, their inhibitory activities toward the Checkpoint 1 kinase (Chk1), and their in… Expand
2007
2007
Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.
Granulatimide and isogranulatimide, natural products isolated from an ascidian, were found to be abrogators of the cell cycle G2… Expand
Highly Cited
2004
Highly Cited
2004
Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide.
Inhibitors of the G(2) DNA damage checkpoint can selectively sensitize cancer cells with mutated p53 to killing by DNA-damaging… Expand
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2001
2001
G2 DNA Damage Checkpoint Inhibition and Antimitotic Activity of 13-Hydroxy-15-oxozoapatlin*
Checkpoints activated in response to DNA damage cause arrest in the G1 and G2 phases of the cell cycle. Inhibitors of the G2… Expand
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2000
2000
Improved synthesis of isogranulatimide, a G2 checkpoint inhibitor. Syntheses Of didemnimide C, isodidemnimide A, neodidemnimide A, 17-methylgranulatimide, and isogranulatimides A-C.
A concise, improved synthesis of isogranulatimide (6), a naturally occurring substance with G2 checkpoint inhibition activity, is… Expand
Highly Cited
1998
Highly Cited
1998
High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide.
Treatment of cancer cells lacking p53 function with G2 checkpoint inhibitors sensitizes them to the toxic effects of DNA damage… Expand
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Highly Cited
1998
Highly Cited
1998
Granulatimide and Isogranulatimide, Aromatic Alkaloids with G2 Checkpoint Inhibition Activity Isolated from the Brazilian Ascidian Didemnum granulatum: Structure Elucidation and Synthesis†
Crude methanol extracts of the ascidian Didemnum granulatum collected in Brazil showed activity in a new screen for G2 cell cycle… Expand
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