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isogranulatimide

National Institutes of Health

Papers overview

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2015
2015
Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential… 
Review
2009
Review
2009
Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2… 
2007
2007
2007
2007
Highly Cited
2004
Highly Cited
2004
Inhibitors of the G(2) DNA damage checkpoint can selectively sensitize cancer cells with mutated p53 to killing by DNA-damaging… 
2001
2001
Checkpoints activated in response to DNA damage cause arrest in the G1 and G2 phases of the cell cycle. Inhibitors of the G2… 
2000
2000
A concise, improved synthesis of isogranulatimide (6), a naturally occurring substance with G2 checkpoint inhibition activity, is… 
Highly Cited
1998
Highly Cited
1998
Treatment of cancer cells lacking p53 function with G2 checkpoint inhibitors sensitizes them to the toxic effects of DNA damage… 
Highly Cited
1998
Highly Cited
1998
Crude methanol extracts of the ascidian Didemnum granulatum collected in Brazil showed activity in a new screen for G2 cell cycle…