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isogranulatimide

 
National Institutes of Health

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2015
2015
Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential… Expand
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2015
2015
Marine organisms have proven to be a promising source of new compounds with activity against tumor cell lines. Granulatimide and… Expand
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2014
2014
The two marine alkaloids granulatimide and isogranulatimide have been shown to inhibit the checkpoint kinase 1 (Chk1), a… Expand
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2012
2012
A series of pyrrolic analogs and two series of regioisomeric pyrazolic analogs of the marine alkaloids granulatimide and… Expand
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2007
2007
The synthesis of new isogranulatimide analogues, their inhibitory activities toward the Checkpoint 1 kinase (Chk1), and their in… Expand
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2004
2004
Inhibitors of the G(2) DNA damage checkpoint can selectively sensitize cancer cells with mutated p53 to killing by DNA-damaging… Expand
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2001
2001
Checkpoints activated in response to DNA damage cause arrest in the G1 and G2 phases of the cell cycle. Inhibitors of the G2… Expand
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2000
2000
A concise, improved synthesis of isogranulatimide (6), a naturally occurring substance with G2 checkpoint inhibition activity, is… Expand
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1998
1998
Treatment of cancer cells lacking p53 function with G2 checkpoint inhibitors sensitizes them to the toxic effects of DNA damage… Expand
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1998
1998
Crude methanol extracts of the ascidian Didemnum granulatum collected in Brazil showed activity in a new screen for G2 cell cycle… Expand
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