isogranulatimide
National Institutes of Health
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Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential…
Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2…
Inhibitors of the G(2) DNA damage checkpoint can selectively sensitize cancer cells with mutated p53 to killing by DNA-damaging…
Checkpoints activated in response to DNA damage cause arrest in the G1 and G2 phases of the cell cycle. Inhibitors of the G2…
A concise, improved synthesis of isogranulatimide (6), a naturally occurring substance with G2 checkpoint inhibition activity, is…
Treatment of cancer cells lacking p53 function with G2 checkpoint inhibitors sensitizes them to the toxic effects of DNA damage…
Crude methanol extracts of the ascidian Didemnum granulatum collected in Brazil showed activity in a new screen for G2 cell cycle…