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isogranulatimide

National Institutes of Health

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2 relations

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ImidazolesIndoles

Papers overview

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2010
2010
Synthèses et évaluations biologiques anti-cancéreuses d'analogues des alcaloïdes marins granulatimide et isogranulatimide, inhibiteurs potentiels du checkpoint G2
La granulatimide et l'isogranulatimide sont deux alcaloides marins de structure imidazo[4,5a]pyrrolo[3,4- c]carbazole decrits… 
2008
2008
Inhibition of Chk1 by the G[subscript 2] DNA damage checkpoint inhibitor isogranulatimide
Inhibitors of the G{sub 2} DNA damage checkpoint can selectively sensitize cancer cells with mutated p53 to killing by DNA… 
2003
2003
Checkpoint inhibition and cell cycle effects of 13-hydroxy-15-oxozoapatlin, ent-kaur-16-en-15-oxo-18-9oic acid, and isogranulatimide
2001
2001
G2 DNA Damage Checkpoint Inhibition and Antimitotic Activity of 13-Hydroxy-15-oxozoapatlin*
Checkpoints activated in response to DNA damage cause arrest in the G1 and G2 phases of the cell cycle. Inhibitors of the G2… 
2001
2001
Molecular orbital calculations, experimental and theoretical UV spectra of granulatimides and didemnimides, biologically active polycyclic heteroaromatic alkaloids from the ascidian Didemnum…
2000
2000
Improved synthesis of isogranulatimide, a G2 checkpoint inhibitor. Syntheses Of didemnimide C, isodidemnimide A, neodidemnimide A, 17-methylgranulatimide, and isogranulatimides A-C.
A concise, improved synthesis of isogranulatimide (6), a naturally occurring substance with G2 checkpoint inhibition activity, is… 
1999
1999
An investigation of the G2 checkpoint
Current approaches to treating cancers often involve the use of drugs that are toxic to both cancer cells and normal cells. Over… 
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