isogranulatimide

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2014
012319982014

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2015
2015
Marine organisms have proven to be a promising source of new compounds with activity against tumor cell lines. Granulatimide and… (More)
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2014
2014
The two marine alkaloids granulatimide and isogranulatimide have been shown to inhibit the checkpoint kinase 1 (Chk1), a… (More)
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2012
2012
A series of pyrrolic analogs and two series of regioisomeric pyrazolic analogs of the marine alkaloids granulatimide and… (More)
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Review
2009
Review
2009
Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2… (More)
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2007
2007
The synthesis of new isogranulatimide analogues, their inhibitory activities toward the Checkpoint 1 kinase (Chk1), and their in… (More)
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2007
2007
Chemical inhibitors of the G2 checkpoint can sensitize p53-defective cancer cells to DNA damage and several are in preclinical or… (More)
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2007
2007
Granulatimide and isogranulatimide, natural products isolated from an ascidian, were found to be abrogators of the cell cycle G2… (More)
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2004
2004
Inhibitors of the G(2) DNA damage checkpoint can selectively sensitize cancer cells with mutated p53 to killing by DNA-damaging… (More)
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2000
2000
A concise, improved synthesis of isogranulatimide (6), a naturally occurring substance with G2 checkpoint inhibition activity, is… (More)
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1998
1998
Treatment of cancer cells lacking p53 function with G2 checkpoint inhibitors sensitizes them to the toxic effects of DNA damage… (More)
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