ipomoeassin B
National Institutes of Health
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Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with single-digit nanomolar potency…
Natural product synthesis has many applications in the field of chemical biology, due to the protein binding affinity to the…
An efficient synthetic route for ipomoeassin F and its tiglate-modified analogues was developed. The route features late-stage…
Ipomoeassin F, a macrolide glycoresin containing an embedded disaccharide, possesses potent in vitro antitumor activity with an…
A concise, flexible, and efficient total synthesis of the cytotoxic resin glycosides ipomoeassin B (1) and ipomoeassin E (2) is…