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iodine I 131 monoclonal antibody CC49
Known as:
131I-MOAB CC49
, I 131 Monoclonal Antibody CC49
, I131 MOAB CC49
A radioimmunoconjugate of the humanized monoclonal antibody CC49 labeled with iodine I 131. Iodine I 131 monoclonal antibody CC49 delivers beta and…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Biodistribution Study of 188 ReLabeled Trisuccin-HuCC 49 and Trisuccin-HuCC 49 ACa 2 Conjugates in Athymic Nude Mice Bearing Intraperitoneal Colon Cancer Xenografts
2007
Corpus ID: 12189706
The t r ihydroxamate bifunctional chelating agent (BCA), trisuccin, has been shown to be a potential ligand for radiolabeling of…
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2002
2002
Actinium-225 conjugates of MAb CC49 and humanized delta CH2CC49.
S. Kennel
,
M. Brechbiel
,
D. Milenic
,
J. Schlom
,
S. Mirzadeh
Cancer Biotherapy and Radiopharmaceuticals
2002
Corpus ID: 31456233
Radioisotopes with moderate half-lives are essential for conventional radioimmunotherapy using tumor-selective MAbs which require…
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2001
2001
Single-Dose versus fractionated radioimmunotherapy of human colon carcinoma xenografts using 131I-labeled multivalent CC49 single-chain fvs.
A. Goel
,
S. Augustine
,
+5 authors
S. Batra
Clinical Cancer Research
2001
Corpus ID: 18148225
The prospects of radiolabeled antibodies in cancer detection and therapy remain promising. However, efforts to achieve cures…
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1999
1999
Radioimmunotherapy of human colon cancer xenografts using a dimeric single-chain Fv antibody construct.
G. Pavlínková
,
B. J. Booth
,
S. Batra
,
D. Colcher
Clinical Cancer Research
1999
Corpus ID: 11668839
Progress in the use of monoclonal antibodies (MAbs) for the treatment of solid tumors is limited by a number of factors…
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1999
1999
Comparison of multiple bolus and continuous injections of 131I-labeled CC49 for therapy in a colon cancer xenograft model.
D. Buchsbaum
,
M. Khazaeli
,
M. Mayo
,
P. Roberson
Clinical Cancer Research
1999
Corpus ID: 17379200
One of the problems in achieving cures with radioimmunotherapy is that hematological toxicity limits the quantity of radiolabeled…
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1997
1997
The intraoperative detection of ovarian adenocarcinoma using radiolabeled CC49 monoclonal antibody and a hand-held gamma-detecting probe.
D. Mcintosh
,
D. Colcher
,
T. Seemayer
,
M. Smith
Cancer Biotherapy and Radiopharmaceuticals
1997
Corpus ID: 10874759
A phase II study to evaluate the safety and efficacy of the 125I-radiolabeled anti-TAG-72 monoclonal antibody, CC49, as a…
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1997
1997
Effect of recombinant alpha-interferon on pharmacokinetics, biodistribution, toxicity, and efficacy of 131I-labeled monoclonal antibody CC49 in breast cancer: a phase II trial.
D. Macey
,
E. Grant
,
+10 authors
J. Murray
Clinical Cancer Research
1997
Corpus ID: 2696821
Preclinical studies have demonstrated that recombinant IFN-alpha (rIFN-alpha) can enhance the tumor associated glycoprotein 72…
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Highly Cited
1995
Highly Cited
1995
Generation, characterization, and in vivo studies of humanized anticarcinoma antibody CC49.
S. Kashmiri
,
L. Shu
,
E. Padlan
,
D. Milenic
,
J. Schlom
,
P. Hand
Hybridoma
1995
Corpus ID: 9390000
Monoclonal antibody (MAb) CC49 reacts with tumor-associated glycoprotein (TAG)-72, a human pancarcinoma antigen. In clinical…
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Highly Cited
1995
Highly Cited
1995
Biological properties of chimeric domain-deleted anticarcinoma immunoglobulins.
D. C. Slavin-Chiorini
,
D. C. Slavin-Chiorini
,
+9 authors
P. Hand
Cancer Research
1995
Corpus ID: 1869475
CC49 is a second-generation monoclonal antibody (MAb) that has high affinity for the tumor-associated pancarcinoma antigen tumor…
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1995
1995
Expansion of mucin-reactive T-helper lymphocytes from patients with colorectal cancer.
Julian A. Kim
,
Edward W. Martin
,
Claudia J. Morgan
,
W. Aldrich
,
P. L. Triozzi
Cancer Biotherapy
1995
Corpus ID: 41463553
The ability to identify and expand effector cells with reactivity against tumor-associated antigens (TAA) is critical for…
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