intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Known as: apoptosis in response to ER stress, endoplasmic reticulum stress-induced apoptosis, intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress 
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in… (More)

Topic mentions per year

Topic mentions per year

2000-2018
0204020002018

Papers overview

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Highly Cited
2008
Highly Cited
2008
The accumulation of misfolded proteins stresses the endoplasmic reticulum (ER) and triggers cell death through activation of the… (More)
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Highly Cited
2007
Highly Cited
2007
Endoplasmic reticulum (ER) stress caused by misfolded proteins or cytotoxic drugs can kill cells and although activation of this… (More)
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2007
2007
Members of the caspase family are essential for many apoptotic programs. We studied mouse embryonic fibroblasts (MEFs) deficient… (More)
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Highly Cited
2006
Highly Cited
2006
Multiple myeloma (MM) is an incurable plasma cell malignancy. The 26S proteasome inhibitor, bortezomib, selectively induces… (More)
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Highly Cited
2006
Highly Cited
2006
Chronic free fatty acid (FFA) exposure induces pancreatic beta-cell death, which may contribute to the development of type 2… (More)
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Highly Cited
2004
Highly Cited
2004
Protein-tyrosine phosphatase 1B (PTP-1B) is the prototypic tyrosine phosphatase whose function in insulin signaling and… (More)
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Highly Cited
2004
Highly Cited
2004
Recent studies have suggested that neuronal death in Alzheimer's disease or ischemia could arise from dysfunction of the… (More)
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Highly Cited
2004
Highly Cited
2004
It has been shown that excess stress to the endoplasmic reticulum (ER) triggers apoptosis, but the mechanisms underlying these… (More)
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Highly Cited
2001
Highly Cited
2001
When accumulation of a malfolded protein in the endoplastic reticulum (ER) is induced by various adverse conditions, such as… (More)
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Highly Cited
2000
Highly Cited
2000
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… (More)
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