Skip to search formSkip to main contentSkip to account menu

intoplicine

Known as: intoplicin, 7H-Benzo(e)pyrido(4,3-b)indol-3-ol, 11-((3-(dimethylamino)propyl)amino)-8-methyl-, 7H-benzo(e)pyrido(4,3-b)indol-3-ol, 11-((3-(dimethylamino)propyl)amino)-8-methyl 
A benzopyridoindole derivative with antineoplastic property. Intoplicine inhibits activities of both topoisomerase I and II via intercalating DNA… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

IndolesPyridines

Narrower (1)

RP 60475F

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Adenocarcinoma of unknown primary: retrospective analysis of chemosensitivity of 313 freshly explanted tumors in a tumor cloning system
Cancer of unknown primary origin is the eighth most common form of malignancy and accounts for up to 10% of all neoplasms… 
1997
1997
Complementary advantages of fluorescence and SIMS microscopies in the study of cellular localization of two new antitumor drugs
Low light level fluorescence microscopy studies have been carried out on MCF7‐P human mammary tumor cells to localize the… 
1994
1994
Activity of intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro.
BACKGROUND Intoplicine (RP60475) is the most active analogue evaluated in the 7H-benzo[e]-pyrido-[4,3-b]-indole series of… 
1993
1993
Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice
SummaryIntoplicine (RP 60475, NSC 645008) is a new 7H-benzo[e]pyrido[4,3-b] indole derivative which interacts with DNA and… 
1993
1993
Determination of intoplicine, a new antitumour drug, in human faeces by normal-phase high-performance liquid chromatography with fluorescence detection.
1993
1993
Determination of intoplicine, a new antitumour drug, in human whole blood and plasma by normal-phase high-performance liquid chromatography with fluorescence detection.
1993
1993
Chemical stability of the new antitumour agent intoplicine in infusion fluids.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)