FAQ

integrin-mediated signaling pathway

Known as: integrin-mediated signalling pathway 
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
02419962018

Papers overview

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2018
2018
Mycobacterium tuberculosis Mce3C promotes mycobacteria entry into macrophages through activation of β2 integrin-mediated signalling pathway.
Establishment of infection by facultative intracellular pathogen Mycobacterium tuberculosis (Mtb) requires adherence to and… (More)
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2016
2016
Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways.
Lunasin is a naturally existing bioactive peptide with an Arg-Gly-Asp (RGD) motif, which competes with integrins to bind with the… (More)
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2014
2014
The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis
Motile cells are capable of sensing the stiffness of the surrounding extracellular matrix through integrin-mediated focal… (More)
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2014
2014
Silencing of miRNA-148a by hypermethylation activates the integrin-mediated signaling pathway in nasopharyngeal carcinoma
MicroRNAs (miRNAs) play a pivotal role in carcinogenesis by suppressing oncogenes or tumor suppressor genes. Various studies have… (More)
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2011
2011
Knockdown of Rab5a expression decreases cancer cell motility and invasion through integrin-mediated signaling pathway
Rab GTPases function as modulators in intracellular transport. Rab5a, a member of the Rab subfamily of small GTPases, is an… (More)
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2010
2010
Cancer stem-like cells can be isolated with drug selection in human ovarian cancer cell line SKOV3.
One emerging model for the development of drug-resistant tumors utilizes a pool of self-renewing malignant progenitors known as… (More)
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2002
2002
A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated
Focal adhesion kinase (FAK) becomes activated and tyrosine-phosphorylated in response to cell adhesion to extracellular matrix… (More)
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1999
1999
The behavior of calpain-generated N- and C-terminal fragments of talin in integrin-mediated signaling pathways.
Our previous results showed that the binding of an adhesive ligand to integrin alphaIIbbeta(3) on the surface of platelets… (More)
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1998
1998
Fluid shear stress activation of IkappaB kinase is integrin-dependent.
Vascular endothelial cells (ECs), forming a boundary between the circulating blood and the vessel wall, are constantly subjected… (More)
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1996
1996
Involvement of calpain in integrin-mediated signal transduction.
An antibody specific to the calpain cleavage site in talin, a cytoskeletal protein, was produced. This antibody selectively… (More)
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