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integrin alphaIIb-beta3 complex

Known as: alphaIIb-beta3 integrin complex, alphaIIb-beta3 integrin complex location, integrin alphaIIb-beta3 complex location 
An integrin complex that comprises one alphaIIb subunit and one beta3 subunit. [PMID:12297042]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
A unique interaction between alphaIIb and beta3 in the head region is essential for outside-in signaling-related functions of alphaIIbbeta3 integrin.
The main interface of the 2 subunits of platelet integrin alphaIIbbeta3 comprises the beta-propeller domain of alphaIIb and the… Expand
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2009
2009
Three-dimensional Model of Human Platelet Integrin αIIbβ3 in Solution Obtained by Small Angle Neutron Scattering*
Integrin αIIbβ3 is the major membrane protein and adhesion receptor at the surface of blood platelets, which after activation… Expand
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2008
2008
αIIbG236E causes Glanzmann thrombasthenia by impairing association with β3
Glanzmann thrombasthenia (GT) is a recessively inherited bleeding disorder caused by the quantitative or qualitative deficiency… Expand
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Review
2006
Review
2006
Redox modification of platelet glycoproteins.
Platelets contain several glycoprotein receptors including the adhesion receptor glycoprotein Ib and the fibrinogen receptor… Expand
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2002
2002
Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients.
Glanzmann's thrombasthenia (GT) is a genetically heterogeneous autosomal recessive syndrome associated with a bleeding tendency… Expand
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1997
1997
A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface.
We report a case of Glanzmann thrombasthenia in a Pakistani child whose platelets express less than 10% of the normal amount of… Expand
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