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integrin alphaIIb-beta3 complex
Known as:
alphaIIb-beta3 integrin complex
, alphaIIb-beta3 integrin complex location
, integrin alphaIIb-beta3 complex location
An integrin complex that comprises one alphaIIb subunit and one beta3 subunit. [PMID:12297042]
National Institutes of Health
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2010
2010
A unique interaction between alphaIIb and beta3 in the head region is essential for outside-in signaling-related functions of alphaIIbbeta3 integrin.
H. Hauschner
,
M. Landau
,
U. Seligsohn
,
N. Rosenberg
Blood
2010
Corpus ID: 20448681
The main interface of the 2 subunits of platelet integrin alphaIIbbeta3 comprises the beta-propeller domain of alphaIIb and the…
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2009
2009
Three-dimensional Model of Human Platelet Integrin αIIbβ3 in Solution Obtained by Small Angle Neutron Scattering*
A. Nogales
,
C. García
,
Javier Pérez
,
P. Callow
,
T. Ezquerra
,
J. González-Rodríguez
Journal of Biological Chemistry
2009
Corpus ID: 23809420
Integrin αIIbβ3 is the major membrane protein and adhesion receptor at the surface of blood platelets, which after activation…
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2008
2008
αIIbG236E causes Glanzmann thrombasthenia by impairing association with β3
A. Afrasiabi
,
F. Gelain
,
A. Artoni
,
P. Mannucci
Platelets
2008
Corpus ID: 205634932
Glanzmann thrombasthenia (GT) is a recessively inherited bleeding disorder caused by the quantitative or qualitative deficiency…
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Review
2006
Review
2006
Redox modification of platelet glycoproteins.
D. Essex
,
M. Li
Current Drug Targets
2006
Corpus ID: 34887244
Platelets contain several glycoprotein receptors including the adhesion receptor glycoprotein Ib and the fibrinogen receptor…
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Highly Cited
2002
Highly Cited
2002
Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients.
G. D’Andrea
,
D. Colaizzo
,
G. Vecchione
,
E. Grandone
,
G. Di Minno
,
M. Margaglione
Thrombosis and Haemostasis
2002
Corpus ID: 30612036
Glanzmann's thrombasthenia (GT) is a genetically heterogeneous autosomal recessive syndrome associated with a bleeding tendency…
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1997
1997
A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface.
R. Basani
,
D. Brown
,
G. Vilaire
,
J. Bennett
,
M. Poncz
Blood
1997
Corpus ID: 2332713
We report a case of Glanzmann thrombasthenia in a Pakistani child whose platelets express less than 10% of the normal amount of…
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