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integrin alphaIIb-beta3 complex

Known as: alphaIIb-beta3 integrin complex, alphaIIb-beta3 integrin complex location, integrin alphaIIb-beta3 complex location 
An integrin complex that comprises one alphaIIb subunit and one beta3 subunit. [PMID:12297042]
National Institutes of Health

Papers overview

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2010
2010
A unique interaction between alphaIIb and beta3 in the head region is essential for outside-in signaling-related functions of alphaIIbbeta3 integrin.
The main interface of the 2 subunits of platelet integrin alphaIIbbeta3 comprises the beta-propeller domain of alphaIIb and the… 
2009
2009
Three-dimensional Model of Human Platelet Integrin αIIbβ3 in Solution Obtained by Small Angle Neutron Scattering*
Integrin αIIbβ3 is the major membrane protein and adhesion receptor at the surface of blood platelets, which after activation… 
2008
2008
αIIbG236E causes Glanzmann thrombasthenia by impairing association with β3
Glanzmann thrombasthenia (GT) is a recessively inherited bleeding disorder caused by the quantitative or qualitative deficiency… 
Review
2006
Review
2006
Redox modification of platelet glycoproteins.
Platelets contain several glycoprotein receptors including the adhesion receptor glycoprotein Ib and the fibrinogen receptor… 
Highly Cited
2002
Highly Cited
2002
Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients.
Glanzmann's thrombasthenia (GT) is a genetically heterogeneous autosomal recessive syndrome associated with a bleeding tendency… 
1997
1997
A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface.
We report a case of Glanzmann thrombasthenia in a Pakistani child whose platelets express less than 10% of the normal amount of… 
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