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inflachromene

 
National Institutes of Health

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1 relation

Broader (1)

Heterocyclic Compounds, 4 or More Rings

Papers overview

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2020
2020
FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome
The crosstalk between deregulated hepatocyte metabolism and cells within the tumour microenvironment, as well as the consequent… Expand
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2019
2019
High mobility group box 1 secretion blockade results in the reduction of early pancreatic islet graft loss.
Pancreatic islet transplantation has been known as the best cure for patients suffering from severe type 1 diabetes mellitus… Expand
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2019
2019
A validated UPLC‐MS/MS method for pharmacokinetic study of inflachromene, a novel microglia inhibitor
&NA; Inflachromene (ICM), a novel microglia inhibitor, is under development to treat neuroinflammatory disorders. For the… Expand
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2018
2018
Inflachromene inhibits autophagy through modulation of Beclin 1 activity
ABSTRACT Autophagy is a central intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and… Expand
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2017
2017
High‐mobility‐group protein 2 regulated by microRNA‐127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells
High‐mobility‐group protein 2 (HMGB2) expression is up‐regulated in human liver cancer; however, little is known about its… Expand
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2017
2017
Treatment of Sepsis Pathogenesis with High Mobility Group Box Protein 1-Regulating Anti-inflammatory Agents.
Sepsis is one of the major causes of death worldwide when associated with multiple organ failure. However, there is a critical… Expand
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2014
2014
A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation.
Because of the critical role of neuroinflammation in various neurological diseases, there are continuous efforts to identify new… Expand
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