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indanocine

Known as: indanosine 
National Institutes of Health

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Indans

Papers overview

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2018
2018
Interaction of microtubule depolymerizing agent indanocine with different human αβ tubulin isotypes
Tubulin isotypes are known to regulate the stability and dynamics of microtubules, and are also involved in the development of… 
2013
2013
Design, synthesis and antiproliferative activity of indole analogues of indanocine
The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative… 
2012
2012
Kinetic stabilization of microtubule dynamics by indanocine perturbs EB1 localization, induces defects in cell polarity and inhibits migration of MDA-MB-231 cells.
2009
2009
Binding of indanocine to the colchicine site on tubulin promotes fluorescence, and its binding parameters resemble those of the colchicine analogue AC.
Indanocine, a synthetic indanone, has shown potential antiproliferative activity against several tumor types. It is different… 
2001
2001
Biochemical genetic analysis of indanocine resistance in human leukemia.
Indanocine is a potent tubulin-binding drug that is cytotoxic to multidrug-resistant cancer cell lines. We demonstrated that… 
2001
2001
Mechanism of Action of Substituted Indanones in Multidrug Resistant Breast Cancer
Abstract : Mechanism of Action of Substituted Indanones in Multidrug Resistant Breast Cancer Our laboratory has recently… 
Highly Cited
2000
Highly Cited
2000
Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells.
BACKGROUND Certain antimitotic drugs have antitumor activities that apparently result from interactions with nontubulin… 
Highly Cited
2000
Highly Cited
2000
Tubulin/microtubules: still a promising target for new chemotherapeutic agents.
Most investigators would agree that the ideal chemotherapeutic agent should be 1) directed at a validated target; 2) potent… 
2000
2000
Tubulin as a target for anticancer drugs.
  • E. von Angerer
  • Current opinion in drug discovery & development
  • 2000
  • Corpus ID: 23591981
Nature provides a large spectrum of agents that either inhibit the polymerization of tubulin or prevent the disassembly of… 
2000
2000
Understanding apoptosis involved in the development and treatment of malignancies
Apoptosis is a key event occurring in living organisms. In order to maintain tissue homeostasis, a comparable number of cells… 
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