indanocine

Tubulin isotypes are known to regulate the stability and dynamics of microtubules, and are also involved in the development of… Expand

The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative… Expand

Cell motility is an essential aspect of metastatic spread of cancer. Microtubule-targeted agents exhibit anti-metastatic… Expand

Indanocine, a synthetic indanone, has shown potential antiproliferative activity against several tumor types. It is different… Expand

Indanocine is a potent tubulin-binding drug that is cytotoxic to multidrug-resistant cancer cell lines. We demonstrated that… Expand

Abstract : Mechanism of Action of Substituted Indanones in Multidrug Resistant Breast Cancer Our laboratory has recently… Expand

BACKGROUND Certain antimitotic drugs have antitumor activities that apparently result from interactions with nontubulin… Expand

Most investigators would agree that the ideal chemotherapeutic agent should be 1) directed at a validated target; 2) potent… Expand

Nature provides a large spectrum of agents that either inhibit the polymerization of tubulin or prevent the disassembly of… Expand

Apoptosis is a key event occurring in living organisms. In order to maintain tissue homeostasis, a comparable number of cells… Expand