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hydroperoxyisophosphamide

Known as: 4-hydroperoxyifosfamide, NSC-227114 
National Institutes of Health

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Broader (1)

Ifosfamide
analogs & derivatives

Papers overview

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Review
2002
Review
2002
Leukemic cell insensitivity to cyclophosphamide and other oxazaphosphorines mediated by aldehyde dehydrogenase(s).
“Acquired” insensitivity to cyclophosphamide and theroxazaphosphorines, e.g., 4-ydroperoxycyclophosphamide (4HC), mafosfamide… 
1997
1997
Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol…
Cytosolic class 3 aldehyde dehydrogenase (ALDH-3) is a demonstrated determinant of cellular sensitivity to the cytotoxic action… 
1997
1997
Effects of WR-2721 (amifostine) and its metabolite WR-1065 on the antiproliferative activity of chemotherapeutic agents on neuroblastoma cells in vitro
Amifostine (WR-2721) is currently being investigated as a potential protector of normal tissues during chemotherapy in adult and… 
1996
1996
Effects of ifosfamide on immunocompetent effector cells.
We analyzed the effects of ifosfamide, a chemotherapeutic agent that is broadly used within anticancer therapy, on… 
1995
1995
Oxime derivatives of the intermediary oncostatic metabolites of cyclophosphamide and ifosfamide: synthesis and deuterium labeling for applications to metabolite quantification.
There is ongoing interest in the selective, quantitative analysis of the cyclophosphamide metabolites 4-hydroxycyclophosphamide… 
1994
1994
Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna
We studied the effects of ifosfamide and major motabolites on intracellular glutathlone (GSH) levels in human peripheral blood… 
1994
1994
Direct detection of the intracellular formation of carboxyphosphamides using nuclear magnetic resonance spectroscopy.
31P nuclear magnetic resonance (NMR) spectroscopy was used in conjunction with cell perfusion techniques to monitor the… 
1977
1977
Synthesis, stereochemistry and antitumor activity of 4-hydroperoxyisophosphamide (NSC-227114) and related compounds.
4-Hydroperoxyisophosphamide and its analogues were simply synthesized by ozonolysis reactions of O-(3-butenyl)-N, N'-bis (2… 
1976
1976
Synthesis of 4-hydroperoxy derivatives of ifosfamide and trofosfamide by direct ozonation and preliminary antitumor evaluation in vivo.
A one-step synthesis of 4-hydroperoxyifosfamide and 4-hydroperoxytrofosfamide is described. The method involves direct ozonation… 
1976
1976
Stereochemistry, metabolism, and antitumor activity of 4-hydroperoxyisophosphamide (NSC-227114) and its stereoisomer.
An acid-catalyzed isomerization of 4-hydroperoxyisophosphamide, a synthetic compound with potential antitumor activity, produced… 
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