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hyaluronan biosynthetic process

Known as: hyaluronan formation, hyaluronan biosynthesis, hyaluronan anabolism 
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of… Expand
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Hyaluronan (HA) has been shown to play crucial roles in the tumorigenicity of malignant tumors. Previous studies demonstrated… Expand
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Highly Cited
2012
Highly Cited
2012
Background: UDP-GlcNAc is a precursor of glycoconjugates, including hyaluronan, and induces protein glycosylation to form O… Expand
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Highly Cited
2009
Highly Cited
2009
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that… Expand
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Review
2008
Review
2008
Microenvironmental stimuli can influence the malignant phenotype of cancer cells. Notably, the altered biosynthesis of hyaluronan… Expand
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Highly Cited
2006
Highly Cited
2006
Vascular endothelial cells are shielded from direct exposure to flowing blood by the endothelial glycocalyx, a highly hydrated… Expand
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Highly Cited
2004
Highly Cited
2004
Specific inhibitors of hyaluronan (HA) biosynthesis can be valuable therapeutic agents to prevent cancer invasion and metastasis… Expand
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Highly Cited
2004
Highly Cited
2004
Malignant transformation of fibroblasts and epithelial cells is often accompanied by increased hyaluronan production and… Expand
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Highly Cited
2003
Highly Cited
2003
During carcinoma progression, tumor cells often undergo changes similar (but not identical) to epithelialmesenchymal transitions… Expand
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Highly Cited
1999
Highly Cited
1999
Three mammalian hyaluronan synthase genes,HAS1, HAS2, and HAS3, have recently been cloned. In this study, we characterized and… Expand
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Highly Cited
1989
Highly Cited
1989
The effect of various growth factors on the synthesis of hyaluronan in human fibroblasts was investigated. When tested in medium… Expand
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