hyaluronan biosynthetic process

Known as: hyaluronan formation, hyaluronan biosynthesis, hyaluronan anabolism 
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
0102019892017

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Highly Cited
2009
Highly Cited
2009
Accumulation of extracellular hyaluronan (HA) and its processing enzyme, the hyaluronidase Hyal1, predicts invasive, metastatic… (More)
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Highly Cited
2009
Highly Cited
2009
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that… (More)
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Highly Cited
2005
Highly Cited
2005
Hyaluronan, a major extracellular matrix component in the epidermis, has been shown to control keratinocyte proliferation and… (More)
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Highly Cited
2004
Highly Cited
2004
Specific inhibitors of hyaluronan (HA) biosynthesis can be valuable therapeutic agents to prevent cancer invasion and metastasis… (More)
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Highly Cited
2003
Highly Cited
2003
During carcinoma progression, tumor cells often undergo changes similar (but not identical) to epithelialmesenchymal transitions… (More)
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Highly Cited
2002
Highly Cited
2002
Hyaluronan (HA), a secreted glycosaminoglycan component of extracellular matrices, is critical for cellular proliferation and… (More)
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Highly Cited
2002
Highly Cited
2002
Elevated hyaluronan biosynthesis and matrix deposition correlates with cell proliferation and migration. We ectopically expressed… (More)
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Highly Cited
1999
Highly Cited
1999
Three mammalian hyaluronan synthase genes, HAS1, HAS2, and HAS3, have recently been cloned. In this study, we characterized and… (More)
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Highly Cited
1998
Highly Cited
1998
The three mammalian hyaluronan synthase (HAS) genes and the related Xenopus laevis gene, DG42, belong to a larger evolutionarily… (More)
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Highly Cited
1989
Highly Cited
1989
The effect of various growth factors on the synthesis of hyaluronan in human fibroblasts was investigated. When tested in medium… (More)
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