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hyaluronan biosynthetic process

Known as: hyaluronan formation, hyaluronan biosynthesis, hyaluronan anabolism 
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of… Expand
National Institutes of Health

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3 relations
negative regulation of hyaluronan biosynthetic processpositive regulation of hyaluronan biosynthetic processregulation of hyaluronan biosynthetic process

Papers overview

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Highly Cited
2012
Highly Cited
2012
Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo.
Hyaluronan (HA) has been shown to play crucial roles in the tumorigenicity of malignant tumors. Previous studies demonstrated… Expand
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Highly Cited
2012
Highly Cited
2012
Role of UDP-N-Acetylglucosamine (GlcNAc) and O-GlcNAcylation of Hyaluronan Synthase 2 in the Control of Chondroitin Sulfate and Hyaluronan Synthesis*
Background: UDP-GlcNAc is a precursor of glycoconjugates, including hyaluronan, and induces protein glycosylation to form O… Expand
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Highly Cited
2009
Highly Cited
2009
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that… Expand
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Review
2008
Review
2008
Altered hyaluronan biosynthesis in cancer progression.
Microenvironmental stimuli can influence the malignant phenotype of cancer cells. Notably, the altered biosynthesis of hyaluronan… Expand
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Highly Cited
2006
Highly Cited
2006
Fluid shear stress stimulates incorporation of hyaluronan into endothelial cell glycocalyx.
Vascular endothelial cells are shielded from direct exposure to flowing blood by the endothelial glycocalyx, a highly hydrated… Expand
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Highly Cited
2004
Highly Cited
2004
A Novel Mechanism for the Inhibition of Hyaluronan Biosynthesis by 4-Methylumbelliferone*
Specific inhibitors of hyaluronan (HA) biosynthesis can be valuable therapeutic agents to prevent cancer invasion and metastasis… Expand
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Highly Cited
2004
Highly Cited
2004
Selective Expression and Functional Characteristics of Three Mammalian Hyaluronan Synthases in Oncogenic Malignant Transformation*
Malignant transformation of fibroblasts and epithelial cells is often accompanied by increased hyaluronan production and… Expand
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Highly Cited
2003
Highly Cited
2003
Elevated Hyaluronan Production Induces Mesenchymal and Transformed Properties in Epithelial Cells*
During carcinoma progression, tumor cells often undergo changes similar (but not identical) to epithelialmesenchymal transitions… Expand
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Highly Cited
1999
Highly Cited
1999
Three Isoforms of Mammalian Hyaluronan Synthases Have Distinct Enzymatic Properties*
Three mammalian hyaluronan synthase genes,HAS1, HAS2, and HAS3, have recently been cloned. In this study, we characterized and… Expand
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Highly Cited
1989
Highly Cited
1989
Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts.
The effect of various growth factors on the synthesis of hyaluronan in human fibroblasts was investigated. When tested in medium… Expand
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