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The medicinal leech Hirudo medicinalis produces various types of proteinase inhibitors: bdellins (inhibitors of trypsin, plasmin… Expand BACKGROUND
Leech-derived inhibitors have a prominent role in the development of new antithrombotic drugs, because some of them… Expand The serine proteinase plasmin is, together with tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator… Expand BACKGROUND
Hirustasin belongs to a class of serine protease inhibitors characterized by a well conserved pattern of cysteine… Expand The three‐dimensional structure of antistasin, a potent inhibitor of blood coagulation factor Xa, from the Mexican leech… Expand A synthetic gene coding for the 55‐amino acid protein hirustasin, a novel tissue kallikrein inhibitor from the leech Hirudo… Expand A new human leukocyte elastase inhibitor was extracted and purified from a Korean native leech Hirudo nipponia. The inhibitor… Expand Antistasin, a potent inhibitor of the blood coagulation factor Xa, is the prototype of a novel family of serine-proteinase… Expand Antistasin is a 119 amino acid protein with anticoagulant, antimetastatic and heparin-binding properties derived from the… Expand Leech‐derived antistasin is a potent anticoagulant and antimetastatic protein that binds sulfatide (Gal(3‐SO4)β1‐1Cer)and… Expand