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hirustasin

Known as: Hirudo antistasin, Proteinase inhibitor, hirustasin, antistasin, Hirudo 
National Institutes of Health

Papers overview

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Review
2004
Review
2004
The medicinal leech Hirudo medicinalis produces various types of proteinase inhibitors: bdellins (inhibitors of trypsin, plasmin… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Leech-derived inhibitors have a prominent role in the development of new antithrombotic drugs, because some of them… Expand
1999
1999
The serine proteinase plasmin is, together with tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator… Expand
1997
1997
BACKGROUND Hirustasin belongs to a class of serine protease inhibitors characterized by a well conserved pattern of cysteine… Expand
1997
1997
The three‐dimensional structure of antistasin, a potent inhibitor of blood coagulation factor Xa, from the Mexican leech… Expand
1997
1997
A synthetic gene coding for the 55‐amino acid protein hirustasin, a novel tissue kallikrein inhibitor from the leech Hirudo… Expand
Highly Cited
1995
Highly Cited
1995
A new human leukocyte elastase inhibitor was extracted and purified from a Korean native leech Hirudo nipponia. The inhibitor… Expand
Highly Cited
1994
Highly Cited
1994
Antistasin, a potent inhibitor of the blood coagulation factor Xa, is the prototype of a novel family of serine-proteinase… Expand
1992
1992
Antistasin is a 119 amino acid protein with anticoagulant, antimetastatic and heparin-binding properties derived from the… Expand
1992
1992
Leech‐derived antistasin is a potent anticoagulant and antimetastatic protein that binds sulfatide (Gal(3‐SO4)β1‐1Cer)and… Expand