چکیده زمینه و هدف: درماتیت آتوپیک یا اگزمای سرشتی، شایع‌ترین بیماری التهابی مزمن و عودکننده دوران نوزادی و کودکی است که به‌ندرت تا بزرگ‌سالی ادامه پیدا می‌کند. و به‌طور شایع، سابقه‌ای از آتوپی (به‌صورت آسم، رینیت آلرژیک یا حساسیت غذایی) همراه بیماری دیده می‌شود. این مطالعه به بررسی تطبیقی درماتیت آتوپیک با بیماریهای التهابی- بثوری در طب سنتی ایران می‌پردازد. تطبیق این بیماری با بیماریهای توصیف شده در طب سنتی ایران به‌عنوان یک طب کل‌نگر، می‌تواند گشایش افق‌های دیگری از شناخت و درمان را در پی داشته باشد. یافته‌ها: هر چند حضور فاکتورهای التهابی در ایجاد درماتیت آتوپیک اثبات شده است، اما پاتوژنز بیماری هنوز به‌طور دقیق شناخته شده نیست. ازآنجایی‌که اطلاعات دقیقی از محل ضایعات، مزمن و عودکننده بودن و سابقه شخصی یا خانوادگی در حساسیت به آلرژن‌ها در کتاب‌های طب سنتی ایران موجود نبوده است، بررسی بیماری به تظاهرات بالینی ذکر شده در منابع طب سنتی ایران محدود شده و این مطالعه بر پایه علائم اصلی بیماری (بثورات التهابی، خارش و خشکی) صورت پذیرفته است. در این پژوهش بیماریهای التهابی- بثوری استخراج شده از منابع طب سنتی ایران از نظر علائم و اسباب ایجاد کننده آن با آنچه در طب نوین به‌عنوان تظاهرات بالینی و پاتوژنز درماتیت آتوپیک نام برده شده، مقایسه گردید. نتیجه‌گیری: در فاز نهایی این پژوهش، از میان این طیف گسترده از بیماریهای التهابی- بثوری با توجه به دو عامل اسباب ایجاد کننده و علائم بیماری، بیشترین شباهت درماتیت آتوپیک با نمله و جاورسیه دیده شد. واژه‌های کلیدی: درماتیت آتوپیک خارش؛ التهاب؛ طب سنتی References - Agili M (2005) [Kholasat al hekmat]. edition. 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PhD in Biomedical Engineering, Biomedical Engineering Department, Faculty of Engineering, Islamic Azad University, South Tehran Branch, Tehran, Iran 3.*MSc, Lecturer, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Abstract: Background and Aim: Atopic Dermatitis (AD) or innate eczema is the most common chronic relapsing inflammatory skin diseases in infantile and childhood, which is rarely continued into adulthood. Family or personal history of atopy (e.g. asthma, allergic rhinitis or food sensitivity) is very common in children suffered from AD. Materials and Methods: Although the role of inflammatory processes in AD is well recognized, the exact pathogenesis of it is not fully understood. Therefore, comparison between AD and diseases described in traditional Iranian medicine (TIM) as a holistic medicine may open new horizons to the deeper comprehension and therapeutic approaches. In this study, we try to draw an analogy between AD and inflammatory skin rashes described in traditional Iranian medicine references. The lack of information of lesion's location, being chronic or recurrent and family or personal history of allergy in traditional Iranian medicine references led us to solely use the clinical manifestation. Hence, according to the major symptoms of AD, inflammatory rashes, pruritus, and xerosis are defined as the clinical manifestation of AD in this study. At the first step, we compare the symptoms and causes of inflammation skin rashes in traditional medicine and clinical manifestation with pathogenesis of AD in modern medicine. In the second step, we extract the similarities and differences between AD and inflammatory skin rashes described in TIM. Conclusion: The results reveal that, Namleh and Javarsiyeh have the most common symptoms to AD, among all diseases described in traditional Iranian medicine. Key words: Dermatitis, Atopic; Inflammation; Medicine, Traditional