heme biosynthetic process

Known as: haem biosynthetic process, heme anabolism, heme synthesis 
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less… (More)
National Institutes of Health

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3 relations
negative regulation of heme biosynthetic processporphyrin biosynthesispositive regulation of heme biosynthetic process

Papers overview

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Highly Cited
2014
Highly Cited
2014
Tracking cancer drugs in living cells by thermal profiling of the proteome
The thermal stability of proteins can be used to assess ligand binding in living cells. We have generalized this concept by… (More)
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Review
2008
Review
2008
The biochemistry of heme biosynthesis.
Heme is an integral part of proteins involved in multiple electron transport chains for energy recovery found in almost all forms… (More)
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Highly Cited
2007
Highly Cited
2007
Selective iron chelation in Friedreich ataxia: biologic and clinical implications.
Genetic disorders of iron metabolism and chronic inflammation often evoke local iron accumulation. In Friedreich ataxia… (More)
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Highly Cited
2006
Highly Cited
2006
Mitoferrin is essential for erythroid iron assimilation
Iron has a fundamental role in many metabolic processes, including electron transport, deoxyribonucleotide synthesis, oxygen… (More)
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Highly Cited
2005
Highly Cited
2005
Lack of heme synthesis in a free-living eukaryote.
In most free-living eukaryotes studied thus far, heme is synthesized from a series of intermediates through a well defined… (More)
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Highly Cited
2005
Highly Cited
2005
Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α
Inducible hepatic porphyrias are inherited genetic disorders of enzymes of heme biosynthesis. The main clinical manifestations… (More)
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Review
2000
Review
2000
The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties.
The heme biosynthetic and catabolic pathways generate pro- and antioxidant compounds, and consequently, influence cellular… (More)
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Review
1999
Review
1999
Cell biology of heme.
  • Prem Ponka
  • The American journal of the medical sciences
  • 1999
Heme is a complex of iron with protoporphyrin IX that is essential for the function of all aerobic cells. Heme serves as the… (More)
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Highly Cited
1998
Highly Cited
1998
The bacterial irr protein is required for coordination of heme biosynthesis with iron availability.
Heme is a ubiquitous macromolecule that serves as the active group of proteins involved in many cellular processes. The… (More)
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Highly Cited
1996
Highly Cited
1996
Characterization of uncultivated prokaryotes: isolation and analysis of a 40-kilobase-pair genome fragment from a planktonic marine archaeon.
One potential approach for characterizing uncultivated prokaryotes from natural assemblages involves genomic analysis of DNA… (More)
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