Semantic Scholar uses AI to extract papers important to this topic.
The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the heart to increased workload… Expand The human heart is believed to grow by enlargement but not proliferation of cardiomyocytes (heart muscle cells) during postnatal… Expand As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and… Expand Heart growth is tightly controlled so that the heart reaches a predetermined size. Fetal heart growth occurs through… Expand A transcriptional coactivator in the Hippo pathway promotes cardiac growth. Growing a Heart Understanding the signaling pathways… Expand Rationale: The developing heart requires both mechanical load and vascularization to reach its proper size, yet the regulation of… Expand Background—Transcatheter balloon aortic valvuloplasty (BAVP) has become the first-line treatment for critical aortic stenosis (AS… Expand Insulin-like growth factor 1 (IGF1) was considered a potential candidate for the treatment of heart failure. However, some animal… Expand Akt is a serine-threonine kinase that mediates a variety of cellular responses to external stimuli. During postnatal development… Expand Organ size is precisely regulated during development, but the control mechanisms remain obscure. We have isolated a mutation in… Expand