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Although glucuronide and sulfate conjugates of many drugs and endogenous compounds undergo appreciable hepatic basolateral… Expand The role of Mrp2, Bcrp, and P-glycoprotein in the biliary excretion of acetaminophen sulfate (AS) and glucuronide (AG), 4… Expand BACKGROUND
Transfected Madin-Darby canine kidney (MDCK) cells (of distal tubular origin) have been used to study transport of… Expand Oatp1, the organic anion transport polypeptide, is an integral membrane protein cloned from rat liver that mediates the uptake of… Expand Sulfation of organic compounds requires activation of inorganic sulfate via formation of adenosine 3'-phosphate 5'-phosphosulfate… Expand In the liver, drugs with phenolic groups can be converted to sulfate or glucuronide conjugates and are then transported into bile… Expand Previous studies in the once-through perfused rat liver preparation have shown that the techniques of normal and retrograde… Expand The role of zonal distributions of metabolic activities (sulfation and glucuronidation) in the liver on the kinetics of harmol… Expand The conjugation of harmol and the disposition of harmol metabolites by isolated rat hepatocytes were investigated. Harmol… Expand Harmol, a phenolic compound of low molecular weight, is conjugated either with glucuronic acid or sulfate. A clear relationship… Expand