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granulin 4

Known as: epithelin-1, CS5931, granulin A 
 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance.
BACKGROUND & AIMS Chemotherapy is used to treat unresectable liver cancer with marginal efficacy; this might result from hepatic… Expand
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2011
2011
Granulin-Epithelin Precursor Is an Oncofetal Protein Defining Hepatic Cancer Stem Cells
Background and Aims Increasing evidence has suggested that hepatocellular carcinoma (HCC) might originate from a distinct… Expand
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Highly Cited
2010
Highly Cited
2010
Granulin epithelin precursor: a bone morphogenic protein 2‐inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis
Granulin epithelin precursor (GEP) has been implicated in development, tissue regeneration, tumorigenesis, and inflammation… Expand
2010
2010
Expression of Progranulin (Acrogranin/PCDGF/Granulin-Epithelin Precursor) in Benign and Malignant Ovarian Tumors and Activation of MAPK Signaling in Ovarian Cancer Cell Line
ABSTRACT It has been recently demonstrated that progranulin is overexpressed in ovarian cancer and that this protein is involved… Expand
Highly Cited
2008
Highly Cited
2008
Granulin‐epithelin precursor as a therapeutic target for hepatocellular carcinoma
Primary liver cancer, hepatocellular carcinoma (HCC), is the fifth most common cancer and the third leading cancer killer in the… Expand
Highly Cited
2007
Highly Cited
2007
Cartilage Oligomeric Matrix Protein Associates with Granulin-Epithelin Precursor (GEP) and Potentiates GEP-stimulated Chondrocyte Proliferation*
Mutations in human cartilage oligomeric matrix protein (COMP) have been linked to the development of pseudoachondroplasia and… Expand
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Highly Cited
2004
Highly Cited
2004
Granulin–Epithelin Precursor Overexpression Promotes Growth and Invasion of Hepatocellular Carcinoma
Purpose: Granulin–epithelin precursor (GEP) is a novel growth factor. Our earlier cDNA microarray study indicated that GEP was… Expand
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1993
1993
Biochemical analysis of the epithelin receptor.
Epithelin 1 and 2 are cysteine-rich proteins that act as growth modulators of epithelial cells. In this report, we have… Expand
Highly Cited
1992
Highly Cited
1992
The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth.
Epithelin 1 and 2 were originally purified from rat kidneys based on their ability to inhibit the growth of A-431 human… Expand
Highly Cited
1990
Highly Cited
1990
Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins.
Two proteins, termed epithelin 1 and epithelin 2, that inhibit the growth of A431 cells, derived from a human epidermal carcinoma… Expand
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