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granulin 4
Known as:
epithelin-1
, CS5931
, granulin A
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance.
Siu Tim Cheung
,
Phyllis F.Y. Cheung
,
Christine K.C. Cheng
,
Nicholas C.L. Wong
,
Sheung Tat Fan
Gastroenterology
2011
Corpus ID: 12148702
BACKGROUND & AIMS Chemotherapy is used to treat unresectable liver cancer with marginal efficacy; this might result from hepatic…
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2011
2011
Granulin-Epithelin Precursor Is an Oncofetal Protein Defining Hepatic Cancer Stem Cells
P. F. Y. Cheung
,
C. Cheng
,
+6 authors
S. Cheung
PloS one
2011
Corpus ID: 15149020
Background and Aims Increasing evidence has suggested that hepatocellular carcinoma (HCC) might originate from a distinct…
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Highly Cited
2010
Highly Cited
2010
Granulin epithelin precursor: a bone morphogenic protein 2‐inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis
J. Feng
,
Feng-jin Guo
,
+6 authors
C. Liu
FASEB journal : official publication of the…
2010
Corpus ID: 5141017
Granulin epithelin precursor (GEP) has been implicated in development, tissue regeneration, tumorigenesis, and inflammation…
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2010
2010
Expression of Progranulin (Acrogranin/PCDGF/Granulin-Epithelin Precursor) in Benign and Malignant Ovarian Tumors and Activation of MAPK Signaling in Ovarian Cancer Cell Line
R. Cuevas-Antonio
,
C. Cancino
,
+11 authors
L. Díaz-Cueto
Cancer investigation
2010
Corpus ID: 207466204
ABSTRACT It has been recently demonstrated that progranulin is overexpressed in ovarian cancer and that this protein is involved…
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Highly Cited
2008
Highly Cited
2008
Granulin‐epithelin precursor as a therapeutic target for hepatocellular carcinoma
Jenny C. Y. Ho
,
Y. C. Ip
,
+4 authors
S. T. Fan
Hepatology
2008
Corpus ID: 205864821
Primary liver cancer, hepatocellular carcinoma (HCC), is the fifth most common cancer and the third leading cancer killer in the…
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Highly Cited
2007
Highly Cited
2007
Cartilage Oligomeric Matrix Protein Associates with Granulin-Epithelin Precursor (GEP) and Potentiates GEP-stimulated Chondrocyte Proliferation*
K. Xu
,
Y. Zhang
,
+4 authors
C. Liu
Journal of Biological Chemistry
2007
Corpus ID: 31378473
Mutations in human cartilage oligomeric matrix protein (COMP) have been linked to the development of pseudoachondroplasia and…
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Highly Cited
2004
Highly Cited
2004
Granulin–Epithelin Precursor Overexpression Promotes Growth and Invasion of Hepatocellular Carcinoma
S. Cheung
,
S. Y. Wong
,
+4 authors
S. T. Fan
Clinical Cancer Research
2004
Corpus ID: 210507
Purpose: Granulin–epithelin precursor (GEP) is a novel growth factor. Our earlier cDNA microarray study indicated that GEP was…
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1993
1993
Biochemical analysis of the epithelin receptor.
J. M. Culouscou
,
G. W. Carlton
,
M. Shoyab
The Journal of biological chemistry
1993
Corpus ID: 12838701
Epithelin 1 and 2 are cysteine-rich proteins that act as growth modulators of epithelial cells. In this report, we have…
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Highly Cited
1992
Highly Cited
1992
The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth.
G. Plowman
,
J. Green
,
+4 authors
M. Shoyab
The Journal of biological chemistry
1992
Corpus ID: 19323243
Epithelin 1 and 2 were originally purified from rat kidneys based on their ability to inhibit the growth of A-431 human…
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Highly Cited
1990
Highly Cited
1990
Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins.
M. Shoyab
,
V. McDonald
,
C. Byles
,
G. Todaro
,
G. Plowman
Proceedings of the National Academy of Sciences…
1990
Corpus ID: 7842024
Two proteins, termed epithelin 1 and epithelin 2, that inhibit the growth of A431 cells, derived from a human epidermal carcinoma…
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