granulin 4

Known as: epithelin-1, CS5931, granulin A 
 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance.
BACKGROUND & AIMS Chemotherapy is used to treat unresectable liver cancer with marginal efficacy; this might result from hepatic… (More)
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2010
2010
Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis.
Granulin epithelin precursor (GEP) has been implicated in development, tissue regeneration, tumorigenesis, and inflammation… (More)
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2010
2010
Expression of progranulin (Acrogranin/PCDGF/Granulin-Epithelin Precursor) in benign and malignant ovarian tumors and activation of MAPK signaling in ovarian cancer cell line.
It has been recently demonstrated that progranulin is overexpressed in ovarian cancer and that this protein is involved in the… (More)
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Highly Cited
2008
Highly Cited
2008
Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma.
UNLABELLED Primary liver cancer, hepatocellular carcinoma (HCC), is the fifth most common cancer and the third leading cancer… (More)
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Highly Cited
2007
Highly Cited
2007
Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation.
Mutations in human cartilage oligomeric matrix protein (COMP) have been linked to the development of pseudoachondroplasia and… (More)
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2007
2007
Prosurvival function of the granulin-epithelin precursor is important in tumor progression and chemoresponse.
The granulin-epithelin precursor (GEP/PCDGF), a 68-88 kDa secreted glycoprotein, has been shown to be an important growth and… (More)
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2005
2005
Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin–epithelin precursor (GEP), a prosurvival factor for ovarian cancer
Granulin-epithelin precursor (GEP/progranulin) is an autocrine growth factor for ovarian cancer. We examined the production and… (More)
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Highly Cited
2004
Highly Cited
2004
Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma.
PURPOSE Granulin-epithelin precursor (GEP) is a novel growth factor. Our earlier cDNA microarray study indicated that GEP was… (More)
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Review
2003
Review
2003
The granulin-epithelin precursor: a putative new growth factor for ovarian cancer.
 
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1993
1993
Biochemical analysis of the epithelin receptor.
Epithelin 1 and 2 are cysteine-rich proteins that act as growth modulators of epithelial cells. In this report, we have… (More)
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