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glycine N-methyltransferase activity
Known as:
S-adenosyl-L-methionine:glycine methyltransferase activity
, glycine methyltransferase activity
, GNMT
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Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. [EC:2.1.1.20]
National Institutes of Health
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Related topics
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1 relation
GNMT gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
N. Martinez-Lopez
,
J. L. García-Rodríguez
,
+14 authors
M. Martínez-Chantar
Gastroenterology
2012
Corpus ID: 36022699
BACKGROUND & AIMS Patients with cirrhosis are at high risk for developing hepatocellular carcinoma (HCC), and their liver tissues…
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Highly Cited
2011
Highly Cited
2011
The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer
Y. Song
,
M. Shiota
,
K. Kuroiwa
,
S. Naito
,
Y. Oda
Modern Pathology
2011
Corpus ID: 24234427
Glycine N-methyltransferase (GNMT) has a role in the metabolism of methionine as well as in gluconeogenesis. It has recently been…
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2009
2009
Impaired liver regeneration in mice lacking glycine N‐methyltransferase
M. Varela-Rey
,
David Fernández-Ramos
,
+10 authors
J. Mato
Hepatology
2009
Corpus ID: 19192413
Hepatic S‐adenosylmethionine (SAMe) is maintained constant by the action of methionine adenosyltransferase I/III (MATI/III…
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2008
2008
Glycine N‐methyltransferase is a favorable prognostic marker for human cholangiocarcinoma
Yu‐Chuen Huang
,
Marcelo Chen
,
+5 authors
Y. Chen
Journal of Gastroenterology and Hepatology
2008
Corpus ID: 24227544
Background and Aim: Glycine N‐methyltransferase (GNMT) is a susceptibility gene for human hepatocellular carcinoma (HCC). We…
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Highly Cited
2007
Highly Cited
2007
Loss of the glycine N‐methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
M. Martínez-Chantar
,
M. Vázquez‐Chantada
,
+14 authors
J. Mato
Hepatology
2007
Corpus ID: 205864616
Glycine N‐methyltransferase (GNMT) is the main enzyme responsible for catabolism of excess hepatic S‐adenosylmethionine (SAMe…
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Highly Cited
2006
Highly Cited
2006
A Glycine N-methyltransferase Knockout Mouse Model for Humans with Deficiency of this Enzyme
Z. Luka
,
A. Capdevila
,
J. Mato
,
C. Wagner
Transgenic research
2006
Corpus ID: 23641842
Three human cases having mutations in the glycine N-methyltransferase (GNMT) gene have been reported. This enzyme transfers a…
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Highly Cited
2004
Highly Cited
2004
Glycine N-Methyltransferase Tumor Susceptibility Gene in the Benzo(a)pyrene-Detoxification Pathway
Shih-Yin Chen
,
Jane-Ru Vivan Lin
,
R. Darbha
,
P. Lin
,
Tsung-Yun Liu
,
Y. Chen
Cancer Research
2004
Corpus ID: 16116351
Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S…
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Highly Cited
2002
Highly Cited
2002
Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats.
M. Rowling
,
M. H. McMullen
,
David C Chipman
,
K. Schalinske
Journal of NutriLife
2002
Corpus ID: 4490089
Glycine N-methyltransferase (GNMT) regulates S-adenosylmethionine (SAM) levels and the ratio of SAM:S-adenosylhomocysteine (SAH…
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2000
2000
Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
Y. Huang
,
J. Komoto
,
+5 authors
F. Takusagawa
Journal of Molecular Biology
2000
Corpus ID: 41509132
Glycine N-methyltransferase (S-adenosyl-l-methionine: glycine methyltransferase, EC 2.1.1.20; GNMT) catalyzes the AdoMet…
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Highly Cited
1994
Highly Cited
1994
Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver.
E. Yeo
,
C. Wagner
Proceedings of the National Academy of Sciences…
1994
Corpus ID: 20176645
Glycine N-methyltransferase (GNMT; S-adenosyl-L-methionine:glycine N-methyltransferase, EC 2.1.1.20) is a major protein in rat…
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