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glycine N-methyltransferase activity

Known as: S-adenosyl-L-methionine:glycine methyltransferase activity, glycine methyltransferase activity, GNMT 
Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. [EC:2.1.1.20]
National Institutes of Health

Papers overview

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2018
2018
The origin of enzyme catalysis remains a question of debate despite much intense study. We report a QM/MM theoretical study of… 
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2012
2012
BACKGROUND & AIMS Patients with cirrhosis are at high risk for developing hepatocellular carcinoma (HCC), and their liver tissues… 
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Highly Cited
2011
Highly Cited
2011
Glycine N-methyltransferase (GNMT) has a role in the metabolism of methionine as well as in gluconeogenesis. It has recently been… 
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2009
2009
Hepatic S‐adenosylmethionine (SAMe) is maintained constant by the action of methionine adenosyltransferase I/III (MATI/III… 
Highly Cited
2008
Highly Cited
2008
Glycine N‐methyltransferase (GNMT) is the main enzyme responsible for catabolism of excess hepatic S‐adenosylmethionine (SAMe… 
Highly Cited
2006
Highly Cited
2006
Three human cases having mutations in the glycine N-methyltransferase (GNMT) gene have been reported. This enzyme transfers a… 
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Highly Cited
2004
Highly Cited
2004
Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S… 
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Highly Cited
2002
Highly Cited
2002
Glycine N-methyltransferase (GNMT) regulates S-adenosylmethionine (SAM) levels and the ratio of SAM:S-adenosylhomocysteine (SAH… 
1997
1997
The cytochrome P-4501A1 (CYP1A1) gene is regulated by several trans-acting factors including the 4 S polycyclic aromatic… 
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Highly Cited
1994
Highly Cited
1994
  • E. Yeo, C. Wagner
  • Proceedings of the National Academy of Sciences…
  • 1994
  • Corpus ID: 20176645
Glycine N-methyltransferase (GNMT; S-adenosyl-L-methionine:glycine N-methyltransferase, EC 2.1.1.20) is a major protein in rat…