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glycine N-methyltransferase activity

Known as: S-adenosyl-L-methionine:glycine methyltransferase activity, glycine methyltransferase activity, GNMT 
Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. [EC:2.1.1.20]
National Institutes of Health

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Related topics

1 relation
GNMT gene

Papers overview

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2018
2018
Insights on the Origin of Catalysis on Glycine N-Methyltransferase from Computational Modeling.
The origin of enzyme catalysis remains a question of debate despite much intense study. We report a QM/MM theoretical study of… Expand
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2016
2016
Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma
Glycine N-methyltransferase (GNMT) expression is vastly downregulated in hepatocellular carcinomas (HCC). High rates of GNMT… Expand
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2009
2009
Impaired liver regeneration in mice lacking glycine N-methyltransferase.
UNLABELLED Hepatic S-adenosylmethionine (SAMe) is maintained constant by the action of methionine adenosyltransferase I/III (MATI… Expand
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Highly Cited
2008
Highly Cited
2008
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
UNLABELLED Glycine N-methyltransferase (GNMT) is the main enzyme responsible for catabolism of excess hepatic S… Expand
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2008
2008
Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma.
BACKGROUND AND AIM Glycine N-methyltransferase (GNMT) is a susceptibility gene for human hepatocellular carcinoma (HCC). We… Expand
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2008
2008
S-adenosylmethionine and proliferation: new pathways, new targets.
SAMe (S-adenosylmethionine) is the main methyl donor group in the cell. MAT (methionine adenosyltransferase) is the unique enzyme… Expand
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Highly Cited
2006
Highly Cited
2006
A Glycine N-methyltransferase Knockout Mouse Model for Humans with Deficiency of this Enzyme
Three human cases having mutations in the glycine N-methyltransferase (GNMT) gene have been reported. This enzyme transfers a… Expand
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Highly Cited
2004
Highly Cited
2004
Glycine N-Methyltransferase Tumor Susceptibility Gene in the Benzo(a)pyrene-Detoxification Pathway
Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S… Expand
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Highly Cited
2002
Highly Cited
2002
Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats.
Glycine N-methyltransferase (GNMT) regulates S-adenosylmethionine (SAM) levels and the ratio of SAM:S-adenosylhomocysteine (SAH… Expand
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Highly Cited
1994
Highly Cited
1994
Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver.
Glycine N-methyltransferase (GNMT; S-adenosyl-L-methionine:glycine N-methyltransferase, EC 2.1.1.20) is a major protein in rat… Expand
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