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glycine N-methyltransferase activity

Known as: S-adenosyl-L-methionine:glycine methyltransferase activity, glycine methyltransferase activity, GNMT 
Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. [EC:2.1.1.20]
National Institutes of Health

Related topics

Related topics

1 relation
GNMT gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Insights on the Origin of Catalysis on Glycine N-Methyltransferase from Computational Modeling.
The origin of enzyme catalysis remains a question of debate despite much intense study. We report a QM/MM theoretical study of… 
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2012
2012
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
BACKGROUND & AIMS Patients with cirrhosis are at high risk for developing hepatocellular carcinoma (HCC), and their liver tissues… 
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Highly Cited
2011
Highly Cited
2011
The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer
Glycine N-methyltransferase (GNMT) has a role in the metabolism of methionine as well as in gluconeogenesis. It has recently been… 
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2009
2009
Impaired liver regeneration in mice lacking glycine N‐methyltransferase
Hepatic S‐adenosylmethionine (SAMe) is maintained constant by the action of methionine adenosyltransferase I/III (MATI/III… 
Highly Cited
2008
Highly Cited
2008
Loss of the glycine N‐methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
Glycine N‐methyltransferase (GNMT) is the main enzyme responsible for catabolism of excess hepatic S‐adenosylmethionine (SAMe… 
Highly Cited
2006
Highly Cited
2006
A Glycine N-methyltransferase Knockout Mouse Model for Humans with Deficiency of this Enzyme
Three human cases having mutations in the glycine N-methyltransferase (GNMT) gene have been reported. This enzyme transfers a… 
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Highly Cited
2004
Highly Cited
2004
Glycine N-Methyltransferase Tumor Susceptibility Gene in the Benzo(a)pyrene-Detoxification Pathway
Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S… 
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Highly Cited
2002
Highly Cited
2002
Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats.
Glycine N-methyltransferase (GNMT) regulates S-adenosylmethionine (SAM) levels and the ratio of SAM:S-adenosylhomocysteine (SAH… 
1997
1997
Glycine N-Methyltransferase Is an Example of Functional Diversity
The cytochrome P-4501A1 (CYP1A1) gene is regulated by several trans-acting factors including the 4 S polycyclic aromatic… 
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Highly Cited
1994
Highly Cited
1994
Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver.
  • E. Yeo, C. Wagner
  • Proceedings of the National Academy of Sciences…
  • 1994
  • Corpus ID: 20176645
Glycine N-methyltransferase (GNMT; S-adenosyl-L-methionine:glycine N-methyltransferase, EC 2.1.1.20) is a major protein in rat… 
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