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glutaminyl-peptide cyclotransferase

Known as: EC 2.3.2.5, Glutaminyl-tRNA Cyclotransferase, sQC 
Glutaminyl-peptide cyclotransferase (361 aa, ~41 kDa) is encoded by the human QPCT gene. This protein is involved in the synthesis of cyclic glutamyl… 
National Institutes of Health

Related topics

Related topics

6 relations
Enzyme GeneExtracellular SpacePost-Translational Protein ProcessingQPCT gene

Broader (2)

QPCT wt Alleleaminoacyltransferase

Papers overview

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Highly Cited
2012
Highly Cited
2012
A differentially selective sensor with fluorescence turn-on response to Zn2+ and dual-mode ratiometric response to Al3+ in aqueous media.
A novel quinoline-coumarin (QC) fluoroionophore conjugated by means of a triazolyl-pyrrolidinyl linker exhibits differential dual… 
Highly Cited
2012
Highly Cited
2012
Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity
The small molecule Quinacrine (QC, a derivative of 9‐aminoacridine), an anti‐malaria drug, displays activity against cancer cell… 
Review
2011
Review
2011
Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease*
Pyroglutamate-modified amyloid-β (AβpE3) peptides are gaining considerable attention as potential key participants in the… 
Review
2009
Review
2009
The Science of USP 1 and 2 Dissolution: Present Challenges and Future Relevance
Since its inception, the dissolution test has come under increasing levels of scrutiny regarding its relevance, especially to the… 
Highly Cited
2009
Highly Cited
2009
Quantitative analysis of colistin A and colistin B in plasma and culture medium using a simple precipitation step followed by LC/MS/MS.
Highly Cited
2008
Highly Cited
2008
Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system.
Highly Cited
2008
Highly Cited
2008
Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.
Compelling evidence suggests that N-terminally truncated and pyroglutamyl-modified amyloid-beta (Abeta) peptides play a major… 
Highly Cited
2004
Highly Cited
2004
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions
Review
1998
Review
1998
Gene discovery in Drosophila: new insights for learning and memory.
Genetic approaches have been used to investigate increasingly complex biological systems. Here we review the current state of… 
Highly Cited
1987
Highly Cited
1987
Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides.
Extracts from bovine pituitary were found to contain an activity catalyzing the conversion of glutaminyl peptides such as [Gln1… 
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