gimeracil

Known as: 5-Chloro-2,4-pyridinediol, 5-chloro-2,4-dihydroxypyridine, CDHP 
A pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2017
0204019872017

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Fluorouracil and folinic acid with either oxaliplatin (FOLFOX) or irinotecan (FOLFIRI) are widely used as first-line… (More)
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Highly Cited
2009
Highly Cited
2009
Dushinsky et al. left a great gift to human beings with the discovery of 5-fluorouracil (5-FU). Approximately 50 years have… (More)
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Highly Cited
2000
Highly Cited
2000
This study set out to evaluate, in patients with metastatic colorectal carcinoma, the efficacy and toxicity of S-1, which… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE To investigate the side effects, determine the maximum-tolerated dose (MTD), and study the pharmacokinetics of S-1, an… (More)
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Highly Cited
1999
Highly Cited
1999
S-1 is a novel oral fluorouracil antitumor drug that combines three pharmacological agents: tegafur (FT), which is a prodrug of 5… (More)
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Highly Cited
1999
Highly Cited
1999
5-Fluorouracil (5-FU) or a 5-FU derivative 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) has been widely prescribed for patients with… (More)
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Highly Cited
1998
Highly Cited
1998
S-1 is a novel oral anticancer drug, composed of tegafur (FT), gimestat (CDHP) and otastat potassium (Oxo) in a molar ratio of 1… (More)
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Highly Cited
1996
Highly Cited
1996
We have focused our attention on the development of a novel form of a tegafur-based [FT; a prodrug of 5-fluorouracil (5-FU… (More)
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Highly Cited
1996
Highly Cited
1996
 S-1, a new oral antitumor agent, is composed of 1-(2-tetrahydrofuryl)-5-fluorouracil (Tegafur, FT), 5-chloro-2,4… (More)
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Highly Cited
1987
Highly Cited
1987
The inhibitory effects of about 30 compounds, mainly pyrimidine and pyridine derivatives, on 5-fluorouracil degradation catalyzed… (More)
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