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gimeracil

Known as: 5-Chloro-2,4-pyridinediol, 5-chloro-2,4-dihydroxypyridine, CDHP 
A pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly… Expand
National Institutes of Health

Papers overview

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Review
2009
Review
2009
Abstract Thymidine phosphorylase (TP), also known as “platelet‐derived endothelial cell growth factor” (PD‐ECGF), is an enzyme… Expand
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Review
2008
Review
2008
Hand-foot syndrome (HFS) is a cutaneous adverse event that occurs in some patients treated with fluoropyrimidines. Although it is… Expand
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2005
2005
The expressions of thymidylate synthase (TS) and intracellular metabolic enzymes have been reported to be associated with the… Expand
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Highly Cited
2003
Highly Cited
2003
PURPOSE Our purpose in the study was to determine the maximum tolerated dose and dose-limiting toxicity and investigate the… Expand
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Highly Cited
2002
Highly Cited
2002
In a clinical study, a newly developed anticancer drug, TS-1 capsule, which contained tegafur (FT) and 5-chloro-2,4… Expand
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Highly Cited
2000
Highly Cited
2000
PURPOSE To investigate the side effects, determine the maximum-tolerated dose (MTD), and study the pharmacokinetics of S-1, an… Expand
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Highly Cited
1998
Highly Cited
1998
S-1 is a novel oral anticancer drug, composed of tegafur (FT), gimestat (CDHP) and otastat potassium (Oxo) in a molar ratio of 1… Expand
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Highly Cited
1997
Highly Cited
1997
A high-performance liquid chromatography (HPLC) and gas chromatography-negative ion chemical ionization mass spectrometry (GC… Expand
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Highly Cited
1996
Highly Cited
1996
We have focused our attention on the development of a novel form of a tegafur-based [FT; a prodrug of 5-fluorouracil (5-FU… Expand
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Highly Cited
1987
Highly Cited
1987
The inhibitory effects of about 30 compounds, mainly pyrimidine and pyridine derivatives, on 5-fluorouracil degradation catalyzed… Expand
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